Abstract
Introduction: Increased inflammatory markers have been found in patients with chronic schizophrenia, and have been associated with negative symptoms. The deficit syndrome is a distinct subtype of schizophrenia, characterized by primary and enduring negative symptoms. Method: We measured inflammatory markers in patients with and without deficit schizophrenia and controls. Results: Using multivariate analyses, tumor necrosis factor (TNF)-α and interleukin-6 were associated with the deficit syndrome, and TNF-α predicted blunted affect, alogia, and total negative symptoms. Conclusions: Findings suggest that deficit schizophrenia subtype is associated with increased inflammation and immunotherapies may be a novel target for negative symptoms.
Original language | English (US) |
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Pages (from-to) | 281-284 |
Number of pages | 4 |
Journal | Schizophrenia Research |
Volume | 199 |
DOIs | |
State | Published - Sep 2018 |
Keywords
- Cytokines
- Deficit syndrome
- Inflammation
- Negative symptoms
- Schizophrenia
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry