TNF-α and IL-6 are associated with the deficit syndrome and negative symptoms in patients with chronic schizophrenia

David R. Goldsmith, Ebrahim Haroon, Andrew H. Miller, Gregory P. Strauss, Peter F Buckley, Brian J Miller

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Introduction: Increased inflammatory markers have been found in patients with chronic schizophrenia, and have been associated with negative symptoms. The deficit syndrome is a distinct subtype of schizophrenia, characterized by primary and enduring negative symptoms. Method: We measured inflammatory markers in patients with and without deficit schizophrenia and controls. Results: Using multivariate analyses, tumor necrosis factor (TNF)-α and interleukin-6 were associated with the deficit syndrome, and TNF-α predicted blunted affect, alogia, and total negative symptoms. Conclusions: Findings suggest that deficit schizophrenia subtype is associated with increased inflammation and immunotherapies may be a novel target for negative symptoms.

Original languageEnglish (US)
Pages (from-to)281-284
Number of pages4
JournalSchizophrenia Research
Volume199
DOIs
StatePublished - Sep 1 2018

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Interleukin-6
Schizophrenia
Tumor Necrosis Factor-alpha
Aphasia
Immunotherapy
Multivariate Analysis
Inflammation

Keywords

  • Cytokines
  • Deficit syndrome
  • Inflammation
  • Negative symptoms
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

TNF-α and IL-6 are associated with the deficit syndrome and negative symptoms in patients with chronic schizophrenia. / Goldsmith, David R.; Haroon, Ebrahim; Miller, Andrew H.; Strauss, Gregory P.; Buckley, Peter F; Miller, Brian J.

In: Schizophrenia Research, Vol. 199, 01.09.2018, p. 281-284.

Research output: Contribution to journalArticle

Goldsmith, David R. ; Haroon, Ebrahim ; Miller, Andrew H. ; Strauss, Gregory P. ; Buckley, Peter F ; Miller, Brian J. / TNF-α and IL-6 are associated with the deficit syndrome and negative symptoms in patients with chronic schizophrenia. In: Schizophrenia Research. 2018 ; Vol. 199. pp. 281-284.
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