Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women

Michele L. Cote, Wonsuk Yoo, Angela S. Wenzlaff, Geoffrey M. Prysak, Susan K. Santer, Gina B. Claeys, Alison L. Van Dyke, Susan J. Land, Ann G. Schwartz

Research output: Contribution to journalArticle

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Abstract

To explore the potential role for estrogen in lung cancer susceptibility, candidate single-nucleotide polymorphism (SNPs) in tobacco and estrogen metabolism genes were evaluated. Population-based cases (n = 504) included women aged 18-74, diagnosed with NSCLC in metropolitan Detroit between November 2001 and October 2005. Population-based controls (n = 527) were identified through random digit dialing and matched on race and age. Eleven SNPs in 10 different genes were examined in relation to risk: CYP1A1 Msp1, CYP1A1 Ile462 Val, CYP1B1 Leu432Val, CYP17, CYP19A1, XRCC1 Gln399 Arg, COMT Val158Met, NQO1 Pro187Ser, GSTM1, GSTT1 and GSTP1 Ile105Val. Lung cancer risk associated with individual SNPs was seen for GSTP1 [A allele; odds ratio (OR) = 1.85; 95% confidence interval (CI), 1.04-3.27] and XRCC1 (A/A genotype; OR = 1.68; 95% CI, 1.01-2.79) in white women and CYP1B1 (G allele; OR = 11.1; 95% CI, 1.18-104) in black women smokers. White women smokers carrying two risk genotypes at the following loci were at increased risk of lung cancer compared with individuals not carrying risk alleles at these loci: CYP17 and GSTM1, COMT and GSTM1, CYP17 and GSTT1, XRCC1 and GSTP1, CYP1B1 and XRCC1 and COMT and XRCC1. The most parsimonious model of lung cancer risk in white smoking women included age, family history of lung cancer, history of chronic lung disease, pack-years, body mass index, XRCC1 A/A genotype, GSTM1 null and COMT A/G or G/G genotype. These findings support the need for continued study of estrogen in relation to lung cancer risk. Polymorphisms in the tobacco metabolism, estrogen metabolism and DNA repair pathways will be useful in developing more predictive models of individual risk.

Original languageEnglish (US)
Pages (from-to)626-635
Number of pages10
JournalCarcinogenesis
Volume30
Issue number4
DOIs
StatePublished - Apr 17 2009
Externally publishedYes

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Non-Small Cell Lung Carcinoma
Tobacco
Estrogens
Lung Neoplasms
Steroid 17-alpha-Hydroxylase
Genotype
Single Nucleotide Polymorphism
Cytochrome P-450 CYP1A1
Alleles
Odds Ratio
Confidence Intervals
Population Control
DNA Repair
Lung Diseases
Genes
Body Mass Index
Chronic Disease
Smoking
Population

ASJC Scopus subject areas

  • Cancer Research

Cite this

Cote, M. L., Yoo, W., Wenzlaff, A. S., Prysak, G. M., Santer, S. K., Claeys, G. B., ... Schwartz, A. G. (2009). Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women. Carcinogenesis, 30(4), 626-635. https://doi.org/10.1093/carcin/bgp033

Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women. / Cote, Michele L.; Yoo, Wonsuk; Wenzlaff, Angela S.; Prysak, Geoffrey M.; Santer, Susan K.; Claeys, Gina B.; Van Dyke, Alison L.; Land, Susan J.; Schwartz, Ann G.

In: Carcinogenesis, Vol. 30, No. 4, 17.04.2009, p. 626-635.

Research output: Contribution to journalArticle

Cote, ML, Yoo, W, Wenzlaff, AS, Prysak, GM, Santer, SK, Claeys, GB, Van Dyke, AL, Land, SJ & Schwartz, AG 2009, 'Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women', Carcinogenesis, vol. 30, no. 4, pp. 626-635. https://doi.org/10.1093/carcin/bgp033
Cote ML, Yoo W, Wenzlaff AS, Prysak GM, Santer SK, Claeys GB et al. Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women. Carcinogenesis. 2009 Apr 17;30(4):626-635. https://doi.org/10.1093/carcin/bgp033
Cote, Michele L. ; Yoo, Wonsuk ; Wenzlaff, Angela S. ; Prysak, Geoffrey M. ; Santer, Susan K. ; Claeys, Gina B. ; Van Dyke, Alison L. ; Land, Susan J. ; Schwartz, Ann G. / Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women. In: Carcinogenesis. 2009 ; Vol. 30, No. 4. pp. 626-635.
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