Toll like receptors signaling pathways as a target for therapeutic interventions

Gnieszka AJezierska, Irina A. Kolosova, Alexander D. Verin

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

This review summarizes the key role of Toll-Like Receptor (TLRs) molecules for igniting the immune system. Activated by a broad spectrum of pathogens, cytokines or other specific molecules, TLRs trigger innate immune responses. Published data demonstrate that the targeting and suppression of TLRs and TLR-related proteins with particular inhibitors may provide pivotal treatments for patients with cancer, asthma, sepsis, Crohn's disease and thrombosis. Many drugs that target cytokines act in the late phases of the activated pathways, after the final peptides, proteins or glycoproteins are formed in the cell environment. TLR activity occurs in the early activation of cellular pathways; consequently inhibiting them might be most beneficial in the treatment of human diseases.

Original languageEnglish (US)
Pages (from-to)428-440
Number of pages13
JournalCurrent Signal Transduction Therapy
Volume6
Issue number3
DOIs
StatePublished - Sep 1 2011

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Keywords

  • Signaling pathways
  • TLR
  • Therapy

ASJC Scopus subject areas

  • Endocrinology
  • Pharmacology (medical)

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