Topoisomerase research of kinetoplastid parasite Leishmania, with special reference to development of therapeutics

Benu Brata Das, Nilkantha Sen, Somdeb Bose Dasgupta, Agneyo Ganguly, Rakhee Das, Hemanta K. Majumder

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Protozoan parasites of the order Kinetoplastida cause severe diseases primarily in the tropical and subtropical areas. The enormous development of molecular and cellular biology in recent times have provided opportunities for discovering newer molecular targets for drug designing, which now form a rational basis for the development of improved anti-parasitic therapy. DNA topoisomerases play a key role in cellular processes affecting the topology and organization of intracellular DNA. Recently, emergence of the bi-subunit topoisomerase I in the kinetoplastid family has brought a new twist in topoisomerase research related to evolution, functional conservation and as a potential target that can be exploited in drug designing and development of new intervention strategies. This review summarizes the biology of kinetoplastid topoisomerases, which are the key molecular targets in antileishmanial chemotherapy.

Original languageEnglish (US)
Pages (from-to)221-232
Number of pages12
JournalIndian Journal of Medical Research
Volume123
Issue number3
StatePublished - Mar 1 2006

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Keywords

  • DNA topoisomerase
  • Kinetoplastids
  • Leishmania
  • Therapeutic targets

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Das, B. B., Sen, N., Dasgupta, S. B., Ganguly, A., Das, R., & Majumder, H. K. (2006). Topoisomerase research of kinetoplastid parasite Leishmania, with special reference to development of therapeutics. Indian Journal of Medical Research, 123(3), 221-232.