TY - CHAP
T1 - Toward a New Era for the Management of Circulating Tumor Cells
AU - Galvis, Marisol Miranda
AU - Romero, Celeste Sánchez
AU - Bueno, Thiago Oliveira
AU - Teng, Yong
N1 - Publisher Copyright:
© 2021, The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG.
PY - 2021
Y1 - 2021
N2 - Circulating tumor cells (CTCs) are malignant cells separate from primary tumors, which can migrate through the peripheral blood, colonize other tissues, and lead to the formation of metastases. The first description of CTCs dates back to 1869 when Thomas Ashworth recognized malignant cells similar to the ones of the primary tumor in the blood vessels of an autopsied patient with metastatic cancer. Currently, CTCs have been identified in various types of cancer and have been recognized for their clinical value in the prediction of prognosis, diagnosis of minimal residual diseases, assessment of tumor sensitivity to anticancer drugs, and personalization of therapies. However, research about these topics has several limitations, principally the rarity of CTCs in bloodstream and their heterogeneous characteristics, which makes detection and isolation difficult. As a result of these limitations, current studies are focused on improvement of isolation and characterization techniques to achieve better sensitivity in clinical applications. This review covers the methods of CTC isolation and detection and current research progression on CTC in different cancer types. The clinical applications, limitations, and perspectives of CTCs are also discussed.
AB - Circulating tumor cells (CTCs) are malignant cells separate from primary tumors, which can migrate through the peripheral blood, colonize other tissues, and lead to the formation of metastases. The first description of CTCs dates back to 1869 when Thomas Ashworth recognized malignant cells similar to the ones of the primary tumor in the blood vessels of an autopsied patient with metastatic cancer. Currently, CTCs have been identified in various types of cancer and have been recognized for their clinical value in the prediction of prognosis, diagnosis of minimal residual diseases, assessment of tumor sensitivity to anticancer drugs, and personalization of therapies. However, research about these topics has several limitations, principally the rarity of CTCs in bloodstream and their heterogeneous characteristics, which makes detection and isolation difficult. As a result of these limitations, current studies are focused on improvement of isolation and characterization techniques to achieve better sensitivity in clinical applications. This review covers the methods of CTC isolation and detection and current research progression on CTC in different cancer types. The clinical applications, limitations, and perspectives of CTCs are also discussed.
KW - Cancer
KW - Circulating tumor cells
KW - Liquid biopsy
KW - Metastasis
KW - Micrometastases
UR - http://www.scopus.com/inward/record.url?scp=85102863733&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85102863733&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-55035-6_9
DO - 10.1007/978-3-030-55035-6_9
M3 - Chapter
C2 - 33725350
AN - SCOPUS:85102863733
T3 - Advances in Experimental Medicine and Biology
SP - 125
EP - 134
BT - Advances in Experimental Medicine and Biology
PB - Springer
ER -