Toxicity assessment of 7 anticancer compounds in zebrafish

Xiao Ping Gao, Feng Feng, Xiao Qi Zhang, Xiao Xin Liu, Yu Bin Wang, Jin-Xiong She, Zhi Heng He, Ming Fang He

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Toxicity is one of the major reasons for failure in drug development. Zebrafish, as an ideal vertebrate model, could also be used to evaluate drug toxicity. In this study, we aimed to show the predictability and highlight novel findings of toxicity in zebrafish model. Seven anticancer compounds, including triptolide (TP), gambogic acid (GA), mycophenolic acid (MPA), curcumin, auranofin, thalidomide, and taxol, were assessed in zebrafish for their toxicity. Three compounds (GA, TP, and taxol) showed highest acute lethality, with 50% lethal concentration ≈ 1 μmol/L. Missing tails, severe pericardial edema, and enlarged yolk sacs were observed in MPA-treated embryos. The development of pectoral fins was severely disturbed in thalidomide-, GA-, and TP-treated embryos. Bradycardia was observed in MPA- and thalidomide-treated groups. Our findings suggested that the zebrafish are a good model for toxicity assessment of anticancer compounds.

Original languageEnglish (US)
Pages (from-to)98-105
Number of pages8
JournalInternational Journal of Toxicology
Volume33
Issue number2
DOIs
StatePublished - Jan 1 2014

Fingerprint

Zebrafish
Mycophenolic Acid
Thalidomide
Toxicity
Paclitaxel
Embryonic Structures
Auranofin
Yolk Sac
Curcumin
Bradycardia
Drug-Related Side Effects and Adverse Reactions
Vertebrates
Tail
Edema
Pharmaceutical Preparations
triptolide
gambogic acid

Keywords

  • acute toxicity
  • anticancer compounds
  • cardiovascular toxicity
  • developmental toxicity
  • zebrafish

ASJC Scopus subject areas

  • Toxicology

Cite this

Gao, X. P., Feng, F., Zhang, X. Q., Liu, X. X., Wang, Y. B., She, J-X., ... He, M. F. (2014). Toxicity assessment of 7 anticancer compounds in zebrafish. International Journal of Toxicology, 33(2), 98-105. https://doi.org/10.1177/1091581814523142

Toxicity assessment of 7 anticancer compounds in zebrafish. / Gao, Xiao Ping; Feng, Feng; Zhang, Xiao Qi; Liu, Xiao Xin; Wang, Yu Bin; She, Jin-Xiong; He, Zhi Heng; He, Ming Fang.

In: International Journal of Toxicology, Vol. 33, No. 2, 01.01.2014, p. 98-105.

Research output: Contribution to journalArticle

Gao, XP, Feng, F, Zhang, XQ, Liu, XX, Wang, YB, She, J-X, He, ZH & He, MF 2014, 'Toxicity assessment of 7 anticancer compounds in zebrafish', International Journal of Toxicology, vol. 33, no. 2, pp. 98-105. https://doi.org/10.1177/1091581814523142
Gao, Xiao Ping ; Feng, Feng ; Zhang, Xiao Qi ; Liu, Xiao Xin ; Wang, Yu Bin ; She, Jin-Xiong ; He, Zhi Heng ; He, Ming Fang. / Toxicity assessment of 7 anticancer compounds in zebrafish. In: International Journal of Toxicology. 2014 ; Vol. 33, No. 2. pp. 98-105.
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