Toxicity of two carbamide peroxide products used in nightguard vital bleaching.

C. J. Woolverton, V. B. Haywood, H. O. Heymann

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

This study evaluated the effects of two generic classes of 10% carbamide-peroxide (CP) oxygenating agents (currently under clinical assessment for nightguard vital tooth bleaching) for lethality and genetic mutation after oral administration to mice, and for cellular cytotoxicity to mouse fibroblasts in vitro. The single dose LD50 values for a non-carbopol-containing CP (Gly-Oxide) and a carbopol-containing CP (Proxigel) in mice were found to be 143.8 mg/kg and 87.2 mg/kg, respectively. Genotoxicity, as measured by the Mouse Micronucleus test for mutagenicity, was negative for both 10% CP agents in comparison with positive and negative controls. Cytotoxicity as measured in the L929 fibroblast lysis assay resulted in 50% killing of L929 fibroblasts at 0.62 for the non-carbopol-containing CP and 1.88 mmol/L for the carbopol-containing CP. Both 10% CP agents were compared with seven widely-used dental products in the L929 fibroblast lysis assay and found to be no more toxic than these products.

Original languageEnglish (US)
Pages (from-to)310-314
Number of pages5
JournalAmerican journal of dentistry
Volume6
Issue number6
StatePublished - Dec 1 1993

ASJC Scopus subject areas

  • Dentistry(all)

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