Transcranial doppler correlation with cerebral angiography in sickle cell disease

Robert J. Adams, Fenwick T Nichols, Ramon E Figueroa Ortiz, Virgil McKie, Thomas Lott

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Background and Purpose: Cerebral infarction in sickle cell disease is associated with arterial narrowing or occlusions of intracranial arteries. Primary stroke prevention would be feasible if a noninvasive screening test could be developed to detect intracranial disease in patients before symptoms develop. Methods: To determine the sensitivity and specificity of transcranial Doppler in detecting significant (≥50% lumen diameter reduction) intracranial arterial lesions, we compared transcranial Doppler and cerebral angiography in a primarily young, symptomatic group of 33 patients (18 males and 15 females) with sickle cell disease. Results: From a total of 34 examinations, transcranial Doppler detected significant abnormalities in 26 of 29 (sensitivity 90%, specificity 100%). Five were normal by both techniques. The transorbital examination detected abnormalities in two patients whose studies were otherwise unremarkable. Conclusions: Transcranial Doppler is sensitive and specific for the detection of arterial vasculopathy of sickle cell disease. Screening should include a transorbital examination of the distal internal carotid artery as well as examination using the transtemporal approach.

Original languageEnglish (US)
Pages (from-to)1073-1077
Number of pages5
JournalStroke
Volume23
Issue number8
DOIs
StatePublished - Jan 1 1992

Fingerprint

Cerebral Angiography
Sickle Cell Anemia
Sensitivity and Specificity
Cerebral Infarction
Internal Carotid Artery
Primary Prevention
Arteries
Stroke

Keywords

  • Anemia
  • Cerebral infarction
  • Child
  • Sickle cell
  • Ultrasonics

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Transcranial doppler correlation with cerebral angiography in sickle cell disease. / Adams, Robert J.; Nichols, Fenwick T; Figueroa Ortiz, Ramon E; McKie, Virgil; Lott, Thomas.

In: Stroke, Vol. 23, No. 8, 01.01.1992, p. 1073-1077.

Research output: Contribution to journalArticle

Adams, Robert J. ; Nichols, Fenwick T ; Figueroa Ortiz, Ramon E ; McKie, Virgil ; Lott, Thomas. / Transcranial doppler correlation with cerebral angiography in sickle cell disease. In: Stroke. 1992 ; Vol. 23, No. 8. pp. 1073-1077.
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