Transcranial Doppler

The influence of age and hematocrit in normal children

R. J. Adams, Fenwick T Nichols, S. Stephens, E. Carl, V. C. McKie, K. McKie, A. Fischer, W. O. Thompson

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A total of 64 healthy children were studied with transcranial Doppler ultrasound (TCD). The purpose was to determine the relative influence of age and hematocrit (HCT) on intracranial arterial velocities and to establish approximate normal ranges for TCD findings based on age. Blood velocities decreased with advancing age and increasing HCT; velocities were highest in young children (aged 4-8) and declined toward adult levels by age 16. Unexpected findings included a significantly higher velocity in girls compared with boys, which was associated with a higher pulse rate but no difference in HCT. Modest left-to-right asymmetries (12 ± 10%) were observed in middle cerebral artery (MCA) velocities. Knowledge of the hematocrit did not add to the prediction of MCA velocities after age and sex were considered. We conclude that intracranial arterial velocities decline with increasing age and HCT in early childhood but that knowledge of the HCT is not necessary to interpret TCD findings in children without severe anemia. Side-to-side asymmetries of up to 30% do not necessarily represent abnormal conditions. Such information will be useful in the application of TCD to the detection of intracranial vessel stenosis in such diseases as moyamoya, sickle cell anemia, and arteritis.

Original languageEnglish (US)
Pages (from-to)201-205
Number of pages5
JournalJournal of Cardiovascular Ultrasonography
Volume7
Issue number3
StatePublished - Jan 1 1988

Fingerprint

Hematocrit
Doppler Ultrasonography
Middle Cerebral Artery
Moyamoya Disease
Arteritis
Sickle Cell Anemia
Anemia
Pathologic Constriction
Reference Values
Heart Rate

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Adams, R. J., Nichols, F. T., Stephens, S., Carl, E., McKie, V. C., McKie, K., ... Thompson, W. O. (1988). Transcranial Doppler: The influence of age and hematocrit in normal children. Journal of Cardiovascular Ultrasonography, 7(3), 201-205.

Transcranial Doppler : The influence of age and hematocrit in normal children. / Adams, R. J.; Nichols, Fenwick T; Stephens, S.; Carl, E.; McKie, V. C.; McKie, K.; Fischer, A.; Thompson, W. O.

In: Journal of Cardiovascular Ultrasonography, Vol. 7, No. 3, 01.01.1988, p. 201-205.

Research output: Contribution to journalArticle

Adams, RJ, Nichols, FT, Stephens, S, Carl, E, McKie, VC, McKie, K, Fischer, A & Thompson, WO 1988, 'Transcranial Doppler: The influence of age and hematocrit in normal children', Journal of Cardiovascular Ultrasonography, vol. 7, no. 3, pp. 201-205.
Adams, R. J. ; Nichols, Fenwick T ; Stephens, S. ; Carl, E. ; McKie, V. C. ; McKie, K. ; Fischer, A. ; Thompson, W. O. / Transcranial Doppler : The influence of age and hematocrit in normal children. In: Journal of Cardiovascular Ultrasonography. 1988 ; Vol. 7, No. 3. pp. 201-205.
@article{1bbc91d691f042deb9dcad214ada7377,
title = "Transcranial Doppler: The influence of age and hematocrit in normal children",
abstract = "A total of 64 healthy children were studied with transcranial Doppler ultrasound (TCD). The purpose was to determine the relative influence of age and hematocrit (HCT) on intracranial arterial velocities and to establish approximate normal ranges for TCD findings based on age. Blood velocities decreased with advancing age and increasing HCT; velocities were highest in young children (aged 4-8) and declined toward adult levels by age 16. Unexpected findings included a significantly higher velocity in girls compared with boys, which was associated with a higher pulse rate but no difference in HCT. Modest left-to-right asymmetries (12 ± 10{\%}) were observed in middle cerebral artery (MCA) velocities. Knowledge of the hematocrit did not add to the prediction of MCA velocities after age and sex were considered. We conclude that intracranial arterial velocities decline with increasing age and HCT in early childhood but that knowledge of the HCT is not necessary to interpret TCD findings in children without severe anemia. Side-to-side asymmetries of up to 30{\%} do not necessarily represent abnormal conditions. Such information will be useful in the application of TCD to the detection of intracranial vessel stenosis in such diseases as moyamoya, sickle cell anemia, and arteritis.",
author = "Adams, {R. J.} and Nichols, {Fenwick T} and S. Stephens and E. Carl and McKie, {V. C.} and K. McKie and A. Fischer and Thompson, {W. O.}",
year = "1988",
month = "1",
day = "1",
language = "English (US)",
volume = "7",
pages = "201--205",
journal = "Journal of Cardiovascular Diagnosis and Procedures",
issn = "0730-8396",
publisher = "M.A. Liebert",
number = "3",

}

TY - JOUR

T1 - Transcranial Doppler

T2 - The influence of age and hematocrit in normal children

AU - Adams, R. J.

AU - Nichols, Fenwick T

AU - Stephens, S.

AU - Carl, E.

AU - McKie, V. C.

AU - McKie, K.

AU - Fischer, A.

AU - Thompson, W. O.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - A total of 64 healthy children were studied with transcranial Doppler ultrasound (TCD). The purpose was to determine the relative influence of age and hematocrit (HCT) on intracranial arterial velocities and to establish approximate normal ranges for TCD findings based on age. Blood velocities decreased with advancing age and increasing HCT; velocities were highest in young children (aged 4-8) and declined toward adult levels by age 16. Unexpected findings included a significantly higher velocity in girls compared with boys, which was associated with a higher pulse rate but no difference in HCT. Modest left-to-right asymmetries (12 ± 10%) were observed in middle cerebral artery (MCA) velocities. Knowledge of the hematocrit did not add to the prediction of MCA velocities after age and sex were considered. We conclude that intracranial arterial velocities decline with increasing age and HCT in early childhood but that knowledge of the HCT is not necessary to interpret TCD findings in children without severe anemia. Side-to-side asymmetries of up to 30% do not necessarily represent abnormal conditions. Such information will be useful in the application of TCD to the detection of intracranial vessel stenosis in such diseases as moyamoya, sickle cell anemia, and arteritis.

AB - A total of 64 healthy children were studied with transcranial Doppler ultrasound (TCD). The purpose was to determine the relative influence of age and hematocrit (HCT) on intracranial arterial velocities and to establish approximate normal ranges for TCD findings based on age. Blood velocities decreased with advancing age and increasing HCT; velocities were highest in young children (aged 4-8) and declined toward adult levels by age 16. Unexpected findings included a significantly higher velocity in girls compared with boys, which was associated with a higher pulse rate but no difference in HCT. Modest left-to-right asymmetries (12 ± 10%) were observed in middle cerebral artery (MCA) velocities. Knowledge of the hematocrit did not add to the prediction of MCA velocities after age and sex were considered. We conclude that intracranial arterial velocities decline with increasing age and HCT in early childhood but that knowledge of the HCT is not necessary to interpret TCD findings in children without severe anemia. Side-to-side asymmetries of up to 30% do not necessarily represent abnormal conditions. Such information will be useful in the application of TCD to the detection of intracranial vessel stenosis in such diseases as moyamoya, sickle cell anemia, and arteritis.

UR - http://www.scopus.com/inward/record.url?scp=0024206446&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024206446&partnerID=8YFLogxK

M3 - Article

VL - 7

SP - 201

EP - 205

JO - Journal of Cardiovascular Diagnosis and Procedures

JF - Journal of Cardiovascular Diagnosis and Procedures

SN - 0730-8396

IS - 3

ER -