Abstract
Background: Simultaneous fluctuation of the inner membrane potential in filamentous mitochondria suggests electrical and functional connection. Results: Transient contraction of mitochondrial matrix induces depolarization through the inner membrane fusion dynamin OPA1. Conclusion: Transient mitochondrial contraction is a previously unrecognized cellular mechanism that induces depolarization. Significance: Transient morphological contraction of mitochondria represents a new mechanism regulating mitochondrial activity.
Original language | English (US) |
---|---|
Pages (from-to) | 11862-11872 |
Number of pages | 11 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 17 |
DOIs | |
State | Published - Apr 25 2014 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology