Transient contraction of mitochondria induces depolarization through the inner membrane dynamin opa1 protein

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Background: Simultaneous fluctuation of the inner membrane potential in filamentous mitochondria suggests electrical and functional connection. Results: Transient contraction of mitochondrial matrix induces depolarization through the inner membrane fusion dynamin OPA1. Conclusion: Transient mitochondrial contraction is a previously unrecognized cellular mechanism that induces depolarization. Significance: Transient morphological contraction of mitochondria represents a new mechanism regulating mitochondrial activity.

Original languageEnglish (US)
Pages (from-to)11862-11872
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number17
DOIs
StatePublished - Apr 25 2014

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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