Background: Simultaneous fluctuation of the inner membrane potential in filamentous mitochondria suggests electrical and functional connection. Results: Transient contraction of mitochondrial matrix induces depolarization through the inner membrane fusion dynamin OPA1. Conclusion: Transient mitochondrial contraction is a previously unrecognized cellular mechanism that induces depolarization. Significance: Transient morphological contraction of mitochondria represents a new mechanism regulating mitochondrial activity.
|Original language||English (US)|
|Number of pages||11|
|Journal||Journal of Biological Chemistry|
|State||Published - Apr 25 2014|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology