Transmission/disequilibrium test analysis of total serum IgE levels in the Hutterite and collaborative study on the genetics of asthma data sets

C. M. Jedrey, C. H. Chen, K. L. Moser, G. C. Wedig, Varghese George, H. K. Tiwari

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The Hutterite and Collaborative Study on the Genetics of Asthma data sets provided by Genetic Analysis Workshop 12 were analyzed using a regression-based transmission/disequilibrium test that assesses linkage between a marker locus and quantitative trait locus when allelic association is present, as proposed by George et al. [Am J Hum Genet 65:236-45, 1999]. Because the same marker set and analytical technique was used, the results from these data sets are amenable for comparison. Statistically significant results common to both data sets were found on chromosomes 1 and 3. A noteworthy result, significant at p < 10-4, was detected on chromosome 18 in the Hutterites.

Original languageEnglish (US)
JournalGenetic Epidemiology
Volume21
Issue numberSUPPL. 1
StatePublished - Oct 23 2001
Externally publishedYes

Fingerprint

Immunoglobulin E
Asthma
Serum
Viverridae
Chromosomes, Human, Pair 18
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 1
Quantitative Trait Loci
Education
Datasets

Keywords

  • Asthma
  • CSGA
  • Disequilibrium
  • Hutterites
  • Linkage
  • Serum IgE
  • Wald test

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

Cite this

Transmission/disequilibrium test analysis of total serum IgE levels in the Hutterite and collaborative study on the genetics of asthma data sets. / Jedrey, C. M.; Chen, C. H.; Moser, K. L.; Wedig, G. C.; George, Varghese; Tiwari, H. K.

In: Genetic Epidemiology, Vol. 21, No. SUPPL. 1, 23.10.2001.

Research output: Contribution to journalArticle

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