Treatment of Cytomegalovirus Retinitis with Ganciclovir

Douglas A. Jabs, Cheryl Newman, Serge De Bustros, B. Frank Polk

Research output: Contribution to journalArticle

134 Scopus citations

Abstract

Eighteen immunocompromised patients with cytomegalovirus (CMV) retinitis were treated with ganciclovir, an investigational antiviral drug. CMV retinitis in association with acquired immune deficiency syndrome (AIDS) developed in 17 patients; CMV retinitis developed in one patient after cardiac transplantation. Fourteen patients responded to ganciclovir treatment with improvement in CMV retinitis. In 11 patients, the response was classified as complete; in three patients, the response was partial. Continued improvement in the retinitis was often seen while the patient was on maintenance treatment. Maintenance ganciclovir therapy was required; relapse occurred in five of seven patients in whom ganciclovir treatment was interrupted. The major limiting toxic side effect of ganciclovir was neutropenia, which necessitated temporary discontinuation of ganciclovir in five patients but was reversible in all cases. Ganciclovir appears to be an effective therapy for CMV retinitis, but chronic maintenance therapy is required.

Original languageEnglish (US)
Pages (from-to)824-830
Number of pages7
JournalOphthalmology
Volume94
Issue number7
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

Keywords

  • acquired immune deficiency syndrome (AIDS)
  • cytomegalovirus retinitis
  • ganciclovir
  • immunocompromised host

ASJC Scopus subject areas

  • Ophthalmology

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