Treatment of early manifestations of Lyme disease

A. C. Steere, G. J. Hutchinson, Daniel Wallace Rahn, L. H. Sigal, J. E. Craft, E. T. DeSanna, S. E. Malawista

Research output: Contribution to journalArticle

303 Citations (Scopus)

Abstract

During 1980 and 1981, we compared antibiotic regimens in 108 adult patients with early Lyme disease. Erythema chronicum migrans and its associated symptoms resolved faster in penicillin- or tetracycline-treated patients than in those given erythromycin (mean duration, 5.4 and 5.7 versus 9.2 days, F = 3.38, p < 0.05). None of 39 patients given tetracycline developed major late complications (meningoencephalitis, myocarditis, or recurrent attacks of arthritis) compared with 3 of 40 penicillin-treated patients and 4 of 29 given erythromycin (chi square with 2 degres of freedom = 5.33, p = 0.07). In 1982, all 49 adult patients were given tetracycline; again, none of them developed major complications. However, with all three antibiotic agents nearly half of the patients had minor late symptoms such as headache, musculoskeletal pain, and lethargy. These complications correlated significantly with the initial severity of illness. For patients with early Lyme disease, tetracycline appears to be the most effective drug, then penicillin, and finally erythromycin.

Original languageEnglish (US)
Pages (from-to)22-26
Number of pages5
JournalUnknown Journal
Volume99
Issue number1
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

Fingerprint

Lyme Disease
Disease
Tetracycline
Erythromycin
pain
Penicillins
illness
drug
Therapeutics
Erythema Chronicum Migrans
Anti-Bacterial Agents
Musculoskeletal Pain
Lethargy
Meningoencephalitis
Myocarditis
Arthritis
Headache
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Steere, A. C., Hutchinson, G. J., Rahn, D. W., Sigal, L. H., Craft, J. E., DeSanna, E. T., & Malawista, S. E. (1983). Treatment of early manifestations of Lyme disease. Unknown Journal, 99(1), 22-26. https://doi.org/10.7326/0003-4819-99-1-22

Treatment of early manifestations of Lyme disease. / Steere, A. C.; Hutchinson, G. J.; Rahn, Daniel Wallace; Sigal, L. H.; Craft, J. E.; DeSanna, E. T.; Malawista, S. E.

In: Unknown Journal, Vol. 99, No. 1, 01.01.1983, p. 22-26.

Research output: Contribution to journalArticle

Steere, AC, Hutchinson, GJ, Rahn, DW, Sigal, LH, Craft, JE, DeSanna, ET & Malawista, SE 1983, 'Treatment of early manifestations of Lyme disease', Unknown Journal, vol. 99, no. 1, pp. 22-26. https://doi.org/10.7326/0003-4819-99-1-22
Steere AC, Hutchinson GJ, Rahn DW, Sigal LH, Craft JE, DeSanna ET et al. Treatment of early manifestations of Lyme disease. Unknown Journal. 1983 Jan 1;99(1):22-26. https://doi.org/10.7326/0003-4819-99-1-22
Steere, A. C. ; Hutchinson, G. J. ; Rahn, Daniel Wallace ; Sigal, L. H. ; Craft, J. E. ; DeSanna, E. T. ; Malawista, S. E. / Treatment of early manifestations of Lyme disease. In: Unknown Journal. 1983 ; Vol. 99, No. 1. pp. 22-26.
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