Treatment of gabapentin-induced myoclonus with continuous renal replacement therapy

A. K. Guddati, Z. Zafar, J. T. Cheng, S. Mohan

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

A 56-year-old man with diabetes, hypertension, and chronic kidney disease presented to the emergency room with a complaint of pain in his right foot. He was found to have tremors. Gabapentin toxicity was suspected and the patient was found to have high gabapentin level (6.3 mcg/ml). Patient was commenced on continuous venovenous hemodiafiltration (CVVHD) and the pharmacokinetics of gabapentin was studied. The patient improved symptomatically and his tremors subsided. In this case report, we describe the successful management of gabapentin toxicity with continuous renal replacement therapy and calculate the clearance of gabapentin which will enable future treatment of gabapentin toxicity by CVVHD.

Original languageEnglish (US)
Pages (from-to)59-61
Number of pages3
JournalIndian Journal of Nephrology
Volume22
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • Clearance
  • dialysis
  • gabapentin
  • toxicity

ASJC Scopus subject areas

  • Nephrology

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