Trimodality approach for ceruminous mucoepidermoid carcinoma of the external auditory canal

Waleed Fouad Mourad, K. S. Hu, R. A. Shourbaji, L. B. Harrison

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Ceruminous mucoepidermoid carcinoma of the external auditory canal is extremely rare. This paper highlights the impact of concurrent chemoradiotherapy on the outcomes of this disease. Case report: A 47-year-old female presented with a 2-month history of otalgia and a mass in her right ear. Biopsy revealed high grade ceruminous mucoepidermoid carcinoma. She underwent surgical excision of the right external auditory canal and right upper neck dissection. Pathological analysis of tumour-node-metastasis staging revealed a T2 N0 (stage II) tumour. One year later, computed tomography scanning of the temporal bone showed tumour recurrence. Biopsy revealed recurrent ceruminous mucoepidermoid carcinoma. The patient underwent salvage resection. Pathology revealed that the tumour was diffusely invading nearby structures, with perineural invasion, lymphatic spread and extracapsular extension. Pathological analysis of tumour-node-metastasis staging revealed a T3 N1 M0 (recurrent stage IV) tumour. Results: The patient subsequently received concurrent chemoradiotherapy. There was no evidence of disease at 37 months' follow up. Conclusion: The trimodality approach, using surgery plus concurrent chemoradiotherapy, provided reasonable loco-regional control with tolerable toxicity. Further detailed case reports are warranted to optimise the management of this rare malignancy.

Original languageEnglish (US)
Pages (from-to)203-206
Number of pages4
JournalJournal of Laryngology and Otology
Volume127
Issue number2
DOIs
StatePublished - Jan 1 2013

Fingerprint

Mucoepidermoid Carcinoma
Ear Canal
Chemoradiotherapy
Neoplasms
Earache
Neoplasm Metastasis
Biopsy
Neck Dissection
Temporal Bone
Ear
Tomography
Pathology
Recurrence

Keywords

  • Cerumen
  • Chemoradiotherapy
  • External Auditory Canal
  • Mucoepidermoid Carcinoma
  • Otologic Surgical Procedures
  • Pathology

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Medicine(all)

Cite this

Trimodality approach for ceruminous mucoepidermoid carcinoma of the external auditory canal. / Mourad, Waleed Fouad; Hu, K. S.; Shourbaji, R. A.; Harrison, L. B.

In: Journal of Laryngology and Otology, Vol. 127, No. 2, 01.01.2013, p. 203-206.

Research output: Contribution to journalArticle

Mourad, Waleed Fouad ; Hu, K. S. ; Shourbaji, R. A. ; Harrison, L. B. / Trimodality approach for ceruminous mucoepidermoid carcinoma of the external auditory canal. In: Journal of Laryngology and Otology. 2013 ; Vol. 127, No. 2. pp. 203-206.
@article{c50a0fde83934bdf9206ded9a74b5375,
title = "Trimodality approach for ceruminous mucoepidermoid carcinoma of the external auditory canal",
abstract = "Background: Ceruminous mucoepidermoid carcinoma of the external auditory canal is extremely rare. This paper highlights the impact of concurrent chemoradiotherapy on the outcomes of this disease. Case report: A 47-year-old female presented with a 2-month history of otalgia and a mass in her right ear. Biopsy revealed high grade ceruminous mucoepidermoid carcinoma. She underwent surgical excision of the right external auditory canal and right upper neck dissection. Pathological analysis of tumour-node-metastasis staging revealed a T2 N0 (stage II) tumour. One year later, computed tomography scanning of the temporal bone showed tumour recurrence. Biopsy revealed recurrent ceruminous mucoepidermoid carcinoma. The patient underwent salvage resection. Pathology revealed that the tumour was diffusely invading nearby structures, with perineural invasion, lymphatic spread and extracapsular extension. Pathological analysis of tumour-node-metastasis staging revealed a T3 N1 M0 (recurrent stage IV) tumour. Results: The patient subsequently received concurrent chemoradiotherapy. There was no evidence of disease at 37 months' follow up. Conclusion: The trimodality approach, using surgery plus concurrent chemoradiotherapy, provided reasonable loco-regional control with tolerable toxicity. Further detailed case reports are warranted to optimise the management of this rare malignancy.",
keywords = "Cerumen, Chemoradiotherapy, External Auditory Canal, Mucoepidermoid Carcinoma, Otologic Surgical Procedures, Pathology",
author = "Mourad, {Waleed Fouad} and Hu, {K. S.} and Shourbaji, {R. A.} and Harrison, {L. B.}",
year = "2013",
month = "1",
day = "1",
doi = "10.1017/S0022215112003015",
language = "English (US)",
volume = "127",
pages = "203--206",
journal = "Journal of Laryngology and Otology",
issn = "0022-2151",
publisher = "Cambridge University Press",
number = "2",

}

TY - JOUR

T1 - Trimodality approach for ceruminous mucoepidermoid carcinoma of the external auditory canal

AU - Mourad, Waleed Fouad

AU - Hu, K. S.

AU - Shourbaji, R. A.

AU - Harrison, L. B.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Background: Ceruminous mucoepidermoid carcinoma of the external auditory canal is extremely rare. This paper highlights the impact of concurrent chemoradiotherapy on the outcomes of this disease. Case report: A 47-year-old female presented with a 2-month history of otalgia and a mass in her right ear. Biopsy revealed high grade ceruminous mucoepidermoid carcinoma. She underwent surgical excision of the right external auditory canal and right upper neck dissection. Pathological analysis of tumour-node-metastasis staging revealed a T2 N0 (stage II) tumour. One year later, computed tomography scanning of the temporal bone showed tumour recurrence. Biopsy revealed recurrent ceruminous mucoepidermoid carcinoma. The patient underwent salvage resection. Pathology revealed that the tumour was diffusely invading nearby structures, with perineural invasion, lymphatic spread and extracapsular extension. Pathological analysis of tumour-node-metastasis staging revealed a T3 N1 M0 (recurrent stage IV) tumour. Results: The patient subsequently received concurrent chemoradiotherapy. There was no evidence of disease at 37 months' follow up. Conclusion: The trimodality approach, using surgery plus concurrent chemoradiotherapy, provided reasonable loco-regional control with tolerable toxicity. Further detailed case reports are warranted to optimise the management of this rare malignancy.

AB - Background: Ceruminous mucoepidermoid carcinoma of the external auditory canal is extremely rare. This paper highlights the impact of concurrent chemoradiotherapy on the outcomes of this disease. Case report: A 47-year-old female presented with a 2-month history of otalgia and a mass in her right ear. Biopsy revealed high grade ceruminous mucoepidermoid carcinoma. She underwent surgical excision of the right external auditory canal and right upper neck dissection. Pathological analysis of tumour-node-metastasis staging revealed a T2 N0 (stage II) tumour. One year later, computed tomography scanning of the temporal bone showed tumour recurrence. Biopsy revealed recurrent ceruminous mucoepidermoid carcinoma. The patient underwent salvage resection. Pathology revealed that the tumour was diffusely invading nearby structures, with perineural invasion, lymphatic spread and extracapsular extension. Pathological analysis of tumour-node-metastasis staging revealed a T3 N1 M0 (recurrent stage IV) tumour. Results: The patient subsequently received concurrent chemoradiotherapy. There was no evidence of disease at 37 months' follow up. Conclusion: The trimodality approach, using surgery plus concurrent chemoradiotherapy, provided reasonable loco-regional control with tolerable toxicity. Further detailed case reports are warranted to optimise the management of this rare malignancy.

KW - Cerumen

KW - Chemoradiotherapy

KW - External Auditory Canal

KW - Mucoepidermoid Carcinoma

KW - Otologic Surgical Procedures

KW - Pathology

UR - http://www.scopus.com/inward/record.url?scp=84876893585&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876893585&partnerID=8YFLogxK

U2 - 10.1017/S0022215112003015

DO - 10.1017/S0022215112003015

M3 - Article

C2 - 23318008

AN - SCOPUS:84876893585

VL - 127

SP - 203

EP - 206

JO - Journal of Laryngology and Otology

JF - Journal of Laryngology and Otology

SN - 0022-2151

IS - 2

ER -