Abstract
ABSTRACT:: Recent studies have introduced the importance of transient receptor potential vanilloid subtype 4 (TRPV4) channels in the regulation of vascular tone. TRPV4 channels are expressed in both endothelium and vascular smooth muscle cells and can be activated by numerous stimuli including mechanical (eg, shear stress, cell swelling, and heat) and chemical (eg, epoxyeicosatrienoic acids, endocannabinoids, and 4α-phorbol esters). In the brain, TRPV4 channels are primarily localized to astrocytic endfeet processes, which wrap around blood vessels. Thus, TRPV4 channels are strategically localized to sense hemodynamic changes and contribute to the regulation of vascular tone. TRPV4 channel activation leads to smooth muscle cell hyperpolarization and vasodilation. Here, we review recent findings on the cellular mechanisms underlying TRPV4-mediated vasodilation; TRPV4 channel interaction with other proteins including transient receptor potential channel 1, small conductance (KCa2.3), and large conductance (KCa1.1) calcium-activated potassium-selective channels; and the importance of caveolin-rich domains for these interactions to take place.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 113-119 |
| Number of pages | 7 |
| Journal | Journal of Cardiovascular Pharmacology |
| Volume | 61 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2013 |
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Keywords
- TRPV4
- astrocytes
- endothelium
- vascular smooth muscle cells
- vasodilation
ASJC Scopus subject areas
- Pharmacology
- Cardiology and Cardiovascular Medicine
Cite this
TRPV4 and the regulation of vascular tone. / Filosa, Jessica A.; Yao, Xiaoqiang; Rath, Geraldine.
In: Journal of Cardiovascular Pharmacology, Vol. 61, No. 2, 01.02.2013, p. 113-119.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - TRPV4 and the regulation of vascular tone
AU - Filosa, Jessica A.
AU - Yao, Xiaoqiang
AU - Rath, Geraldine
PY - 2013/2/1
Y1 - 2013/2/1
N2 - ABSTRACT:: Recent studies have introduced the importance of transient receptor potential vanilloid subtype 4 (TRPV4) channels in the regulation of vascular tone. TRPV4 channels are expressed in both endothelium and vascular smooth muscle cells and can be activated by numerous stimuli including mechanical (eg, shear stress, cell swelling, and heat) and chemical (eg, epoxyeicosatrienoic acids, endocannabinoids, and 4α-phorbol esters). In the brain, TRPV4 channels are primarily localized to astrocytic endfeet processes, which wrap around blood vessels. Thus, TRPV4 channels are strategically localized to sense hemodynamic changes and contribute to the regulation of vascular tone. TRPV4 channel activation leads to smooth muscle cell hyperpolarization and vasodilation. Here, we review recent findings on the cellular mechanisms underlying TRPV4-mediated vasodilation; TRPV4 channel interaction with other proteins including transient receptor potential channel 1, small conductance (KCa2.3), and large conductance (KCa1.1) calcium-activated potassium-selective channels; and the importance of caveolin-rich domains for these interactions to take place.
AB - ABSTRACT:: Recent studies have introduced the importance of transient receptor potential vanilloid subtype 4 (TRPV4) channels in the regulation of vascular tone. TRPV4 channels are expressed in both endothelium and vascular smooth muscle cells and can be activated by numerous stimuli including mechanical (eg, shear stress, cell swelling, and heat) and chemical (eg, epoxyeicosatrienoic acids, endocannabinoids, and 4α-phorbol esters). In the brain, TRPV4 channels are primarily localized to astrocytic endfeet processes, which wrap around blood vessels. Thus, TRPV4 channels are strategically localized to sense hemodynamic changes and contribute to the regulation of vascular tone. TRPV4 channel activation leads to smooth muscle cell hyperpolarization and vasodilation. Here, we review recent findings on the cellular mechanisms underlying TRPV4-mediated vasodilation; TRPV4 channel interaction with other proteins including transient receptor potential channel 1, small conductance (KCa2.3), and large conductance (KCa1.1) calcium-activated potassium-selective channels; and the importance of caveolin-rich domains for these interactions to take place.
KW - TRPV4
KW - astrocytes
KW - endothelium
KW - vascular smooth muscle cells
KW - vasodilation
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UR - http://www.scopus.com/inward/citedby.url?scp=84873408820&partnerID=8YFLogxK
U2 - 10.1097/FJC.0b013e318279ba42
DO - 10.1097/FJC.0b013e318279ba42
M3 - Article
C2 - 23107877
AN - SCOPUS:84873408820
VL - 61
SP - 113
EP - 119
JO - Journal of Cardiovascular Pharmacology
JF - Journal of Cardiovascular Pharmacology
SN - 0160-2446
IS - 2
ER -