Two generations of synthetic membranes for biological/medical applications

J. P. Kennedy, K. S. Rosenthal, B. Kashibhatla

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Two generations of amphiphilic membranes synthesized in our laboratories for biological/medical applications are highlighted. Recent results obtained with representative 2nd generation membranes designed specifically for immunoencapsulation of pancreatic islets and cells are summarized. The latter tri-component membranes comprise well-defined hydrophilic poly(ethylene glycol) and hydrophobic/oxyphilic polydimethylsiloxane segments crosslinked by oxyphilic polycyclosiloxane domains, which also provide reinforcement. Select membranes are demonstrated to allow the diffusion of glucose and insulin but prevent the permeation of immunoglobulin G. These membranes remain permeable despite long incubation in IgG solution.

Original languageEnglish (US)
Pages (from-to)485-494
Number of pages10
JournalDesigned Monomers and Polymers
Volume7
Issue number6 SPEC. ISS.
DOIs
StatePublished - Dec 1 2004
Externally publishedYes

Keywords

  • Amphiphilic membranes
  • Glucose diffusion
  • Immunoisolation
  • Insulin diffusion
  • Selective permeability

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Polymers and Plastics
  • Materials Chemistry

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