Abstract
Two generations of amphiphilic membranes synthesized in our laboratories for biological/medical applications are highlighted. Recent results obtained with representative 2nd generation membranes designed specifically for immunoencapsulation of pancreatic islets and cells are summarized. The latter tri-component membranes comprise well-defined hydrophilic poly(ethylene glycol) and hydrophobic/oxyphilic polydimethylsiloxane segments crosslinked by oxyphilic polycyclosiloxane domains, which also provide reinforcement. Select membranes are demonstrated to allow the diffusion of glucose and insulin but prevent the permeation of immunoglobulin G. These membranes remain permeable despite long incubation in IgG solution.
Original language | English (US) |
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Pages (from-to) | 485-494 |
Number of pages | 10 |
Journal | Designed Monomers and Polymers |
Volume | 7 |
Issue number | 6 SPEC. ISS. |
DOIs | |
State | Published - 2004 |
Externally published | Yes |
Keywords
- Amphiphilic membranes
- Glucose diffusion
- Immunoisolation
- Insulin diffusion
- Selective permeability
ASJC Scopus subject areas
- General Chemistry
- General Chemical Engineering
- Polymers and Plastics
- Materials Chemistry