Two members of the SIBLING family of proteins, DSPP and BSP, may predict the transition of oral epithelial dysplasia to oral squamous cell carcinoma

Kalu U.E. Ogbureke, Rafik A Abdelsayed, Harvey Kushner, Li Li, Larry W. Fisher

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

BACKGROUND: Patients with oral premalignant lesions (OPL) present with oral squamous cell carcinomas (OSCC) at a much higher rate than the general population. There are currently no useful markers that indicate specifically which OPLs are most likely to progress. Three small integrin binding ligands N-linked glycoprotein (SIBLING) family proteins, bone sialoprotein (BSP), osteopontin (OPN), and dentin sialophosphoprotein (DSPP), have been shown to be upregulated in many cancers, including OSCC. The status of SIBLING expression in OPLs and their correlation to transition to oral cancer are unknown. METHODS: Sixty archival surgical biopsies of dysplastic OPLs were evaluated by immunohistochemistry for expression of BSP, DSPP, and OPN and correlated with local transformation to OSCC at sites adjacent to surgically removed dysplastic OPL. RESULTS: The OPL patient population was representative of previous studies with 20% progressing to OSCC, and no correlation between degree of dysplasia and progression. Eighty-seven percent were positive for at least 1 SIBLING protein. OPN expression had no correlation with progression. The BSP+/DSPP- expression pattern however correlated with decreased transformation to OSCC (point prevalence = 0%; 95% confidence interval [CI], 0-20.6), whereas the BSP-/DSPP+ pattern was associated with more frequent progression (point prevalence = 77.8%; 95%CI, 47.8-95.4). Incrementally higher expression scores (0 to 3) of BSP and DSPP were also associated with increased predictive values (odds ratio, 25.53; 95% CI, 2.14-304.7 and 10.13; 95% CI, 2.0-50.0, respectively, for each increment). CONCLUSIONS: BSP and DSPP are excellent candidate markers for successful OPL surgical intervention and may be predictors of OPL-OSCC progression.

Original languageEnglish (US)
Pages (from-to)1709-1717
Number of pages9
JournalCancer
Volume116
Issue number7
DOIs
StatePublished - Apr 1 2010

Fingerprint

Integrin-Binding Sialoprotein
Integrins
Squamous Cell Carcinoma
Glycoproteins
Ligands
Osteopontin
Confidence Intervals
Proteins
Mouth Neoplasms
Population
dentin sialophosphoprotein
Immunohistochemistry
Odds Ratio
Biopsy

Keywords

  • BSP
  • Biomarkers
  • DSPP
  • Dysplasia
  • OPN
  • Oral cancer
  • Oral premalignant lesions
  • SIBLINGs
  • Transition

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Two members of the SIBLING family of proteins, DSPP and BSP, may predict the transition of oral epithelial dysplasia to oral squamous cell carcinoma. / Ogbureke, Kalu U.E.; Abdelsayed, Rafik A; Kushner, Harvey; Li, Li; Fisher, Larry W.

In: Cancer, Vol. 116, No. 7, 01.04.2010, p. 1709-1717.

Research output: Contribution to journalArticle

@article{3a7fcec796134df585f5ef83760601c1,
title = "Two members of the SIBLING family of proteins, DSPP and BSP, may predict the transition of oral epithelial dysplasia to oral squamous cell carcinoma",
abstract = "BACKGROUND: Patients with oral premalignant lesions (OPL) present with oral squamous cell carcinomas (OSCC) at a much higher rate than the general population. There are currently no useful markers that indicate specifically which OPLs are most likely to progress. Three small integrin binding ligands N-linked glycoprotein (SIBLING) family proteins, bone sialoprotein (BSP), osteopontin (OPN), and dentin sialophosphoprotein (DSPP), have been shown to be upregulated in many cancers, including OSCC. The status of SIBLING expression in OPLs and their correlation to transition to oral cancer are unknown. METHODS: Sixty archival surgical biopsies of dysplastic OPLs were evaluated by immunohistochemistry for expression of BSP, DSPP, and OPN and correlated with local transformation to OSCC at sites adjacent to surgically removed dysplastic OPL. RESULTS: The OPL patient population was representative of previous studies with 20{\%} progressing to OSCC, and no correlation between degree of dysplasia and progression. Eighty-seven percent were positive for at least 1 SIBLING protein. OPN expression had no correlation with progression. The BSP+/DSPP- expression pattern however correlated with decreased transformation to OSCC (point prevalence = 0{\%}; 95{\%} confidence interval [CI], 0-20.6), whereas the BSP-/DSPP+ pattern was associated with more frequent progression (point prevalence = 77.8{\%}; 95{\%}CI, 47.8-95.4). Incrementally higher expression scores (0 to 3) of BSP and DSPP were also associated with increased predictive values (odds ratio, 25.53; 95{\%} CI, 2.14-304.7 and 10.13; 95{\%} CI, 2.0-50.0, respectively, for each increment). CONCLUSIONS: BSP and DSPP are excellent candidate markers for successful OPL surgical intervention and may be predictors of OPL-OSCC progression.",
keywords = "BSP, Biomarkers, DSPP, Dysplasia, OPN, Oral cancer, Oral premalignant lesions, SIBLINGs, Transition",
author = "Ogbureke, {Kalu U.E.} and Abdelsayed, {Rafik A} and Harvey Kushner and Li Li and Fisher, {Larry W.}",
year = "2010",
month = "4",
day = "1",
doi = "10.1002/cncr.24938",
language = "English (US)",
volume = "116",
pages = "1709--1717",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "7",

}

TY - JOUR

T1 - Two members of the SIBLING family of proteins, DSPP and BSP, may predict the transition of oral epithelial dysplasia to oral squamous cell carcinoma

AU - Ogbureke, Kalu U.E.

AU - Abdelsayed, Rafik A

AU - Kushner, Harvey

AU - Li, Li

AU - Fisher, Larry W.

PY - 2010/4/1

Y1 - 2010/4/1

N2 - BACKGROUND: Patients with oral premalignant lesions (OPL) present with oral squamous cell carcinomas (OSCC) at a much higher rate than the general population. There are currently no useful markers that indicate specifically which OPLs are most likely to progress. Three small integrin binding ligands N-linked glycoprotein (SIBLING) family proteins, bone sialoprotein (BSP), osteopontin (OPN), and dentin sialophosphoprotein (DSPP), have been shown to be upregulated in many cancers, including OSCC. The status of SIBLING expression in OPLs and their correlation to transition to oral cancer are unknown. METHODS: Sixty archival surgical biopsies of dysplastic OPLs were evaluated by immunohistochemistry for expression of BSP, DSPP, and OPN and correlated with local transformation to OSCC at sites adjacent to surgically removed dysplastic OPL. RESULTS: The OPL patient population was representative of previous studies with 20% progressing to OSCC, and no correlation between degree of dysplasia and progression. Eighty-seven percent were positive for at least 1 SIBLING protein. OPN expression had no correlation with progression. The BSP+/DSPP- expression pattern however correlated with decreased transformation to OSCC (point prevalence = 0%; 95% confidence interval [CI], 0-20.6), whereas the BSP-/DSPP+ pattern was associated with more frequent progression (point prevalence = 77.8%; 95%CI, 47.8-95.4). Incrementally higher expression scores (0 to 3) of BSP and DSPP were also associated with increased predictive values (odds ratio, 25.53; 95% CI, 2.14-304.7 and 10.13; 95% CI, 2.0-50.0, respectively, for each increment). CONCLUSIONS: BSP and DSPP are excellent candidate markers for successful OPL surgical intervention and may be predictors of OPL-OSCC progression.

AB - BACKGROUND: Patients with oral premalignant lesions (OPL) present with oral squamous cell carcinomas (OSCC) at a much higher rate than the general population. There are currently no useful markers that indicate specifically which OPLs are most likely to progress. Three small integrin binding ligands N-linked glycoprotein (SIBLING) family proteins, bone sialoprotein (BSP), osteopontin (OPN), and dentin sialophosphoprotein (DSPP), have been shown to be upregulated in many cancers, including OSCC. The status of SIBLING expression in OPLs and their correlation to transition to oral cancer are unknown. METHODS: Sixty archival surgical biopsies of dysplastic OPLs were evaluated by immunohistochemistry for expression of BSP, DSPP, and OPN and correlated with local transformation to OSCC at sites adjacent to surgically removed dysplastic OPL. RESULTS: The OPL patient population was representative of previous studies with 20% progressing to OSCC, and no correlation between degree of dysplasia and progression. Eighty-seven percent were positive for at least 1 SIBLING protein. OPN expression had no correlation with progression. The BSP+/DSPP- expression pattern however correlated with decreased transformation to OSCC (point prevalence = 0%; 95% confidence interval [CI], 0-20.6), whereas the BSP-/DSPP+ pattern was associated with more frequent progression (point prevalence = 77.8%; 95%CI, 47.8-95.4). Incrementally higher expression scores (0 to 3) of BSP and DSPP were also associated with increased predictive values (odds ratio, 25.53; 95% CI, 2.14-304.7 and 10.13; 95% CI, 2.0-50.0, respectively, for each increment). CONCLUSIONS: BSP and DSPP are excellent candidate markers for successful OPL surgical intervention and may be predictors of OPL-OSCC progression.

KW - BSP

KW - Biomarkers

KW - DSPP

KW - Dysplasia

KW - OPN

KW - Oral cancer

KW - Oral premalignant lesions

KW - SIBLINGs

KW - Transition

UR - http://www.scopus.com/inward/record.url?scp=77950209660&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950209660&partnerID=8YFLogxK

U2 - 10.1002/cncr.24938

DO - 10.1002/cncr.24938

M3 - Article

C2 - 20186700

AN - SCOPUS:77950209660

VL - 116

SP - 1709

EP - 1717

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 7

ER -