Abstract
Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.
Original language | English (US) |
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Pages (from-to) | 2538-2541.e6 |
Journal | Fertility and sterility |
Volume | 95 |
Issue number | 8 |
DOIs | |
State | Published - Jun 30 2011 |
Keywords
- Polycystic ovary syndrome (PCOS)
- SNP
- transmission disequilibrium test (TDT)
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology