Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome

Kathryn G. Ewens, Michelle R. Jones, Wendy Ankener, Douglas R. Stewart, Margrit Urbanek, Andrea Dunaif, Richard S. Legro, Angela Chua, Ricardo Azziz, Richard S. Spielman, Mark O. Goodarzi, Jerome F. Strauss

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.

Original languageEnglish (US)
JournalFertility and sterility
Volume95
Issue number8
DOIs
StatePublished - Jun 30 2011

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Polycystic Ovary Syndrome
Type 2 Diabetes Mellitus
Single Nucleotide Polymorphism
Menstrual Cycle
Siblings
Control Groups
Genes

Keywords

  • Polycystic ovary syndrome (PCOS)
  • SNP
  • transmission disequilibrium test (TDT)

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome. / Ewens, Kathryn G.; Jones, Michelle R.; Ankener, Wendy; Stewart, Douglas R.; Urbanek, Margrit; Dunaif, Andrea; Legro, Richard S.; Chua, Angela; Azziz, Ricardo; Spielman, Richard S.; Goodarzi, Mark O.; Strauss, Jerome F.

In: Fertility and sterility, Vol. 95, No. 8, 30.06.2011.

Research output: Contribution to journalArticle

Ewens, KG, Jones, MR, Ankener, W, Stewart, DR, Urbanek, M, Dunaif, A, Legro, RS, Chua, A, Azziz, R, Spielman, RS, Goodarzi, MO & Strauss, JF 2011, 'Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome', Fertility and sterility, vol. 95, no. 8. https://doi.org/10.1016/j.fertnstert.2011.02.050
Ewens, Kathryn G. ; Jones, Michelle R. ; Ankener, Wendy ; Stewart, Douglas R. ; Urbanek, Margrit ; Dunaif, Andrea ; Legro, Richard S. ; Chua, Angela ; Azziz, Ricardo ; Spielman, Richard S. ; Goodarzi, Mark O. ; Strauss, Jerome F. / Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome. In: Fertility and sterility. 2011 ; Vol. 95, No. 8.
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