Abstract
Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.
| Original language | English (US) |
|---|---|
| Journal | Fertility and sterility |
| Volume | 95 |
| Issue number | 8 |
| DOIs | |
| State | Published - Jun 30 2011 |
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Keywords
- Polycystic ovary syndrome (PCOS)
- SNP
- transmission disequilibrium test (TDT)
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology
Cite this
Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome. / Ewens, Kathryn G.; Jones, Michelle R.; Ankener, Wendy; Stewart, Douglas R.; Urbanek, Margrit; Dunaif, Andrea; Legro, Richard S.; Chua, Angela; Azziz, Ricardo; Spielman, Richard S.; Goodarzi, Mark O.; Strauss, Jerome F.
In: Fertility and sterility, Vol. 95, No. 8, 30.06.2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome
AU - Ewens, Kathryn G.
AU - Jones, Michelle R.
AU - Ankener, Wendy
AU - Stewart, Douglas R.
AU - Urbanek, Margrit
AU - Dunaif, Andrea
AU - Legro, Richard S.
AU - Chua, Angela
AU - Azziz, Ricardo
AU - Spielman, Richard S.
AU - Goodarzi, Mark O.
AU - Strauss, Jerome F.
PY - 2011/6/30
Y1 - 2011/6/30
N2 - Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.
AB - Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.
KW - Polycystic ovary syndrome (PCOS)
KW - SNP
KW - transmission disequilibrium test (TDT)
UR - http://www.scopus.com/inward/record.url?scp=79959741221&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79959741221&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2011.02.050
DO - 10.1016/j.fertnstert.2011.02.050
M3 - Article
C2 - 21444075
AN - SCOPUS:79959741221
VL - 95
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 8
ER -