Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome

Kathryn G. Ewens; Michelle R. Jones; Wendy Ankener; Douglas R. Stewart; Margrit Urbanek; Andrea Dunaif; Richard S. Legro; Angela Chua; Ricardo Azziz; Richard S. Spielman; Mark O. Goodarzi; Jerome F. Strauss

doi:10.1016/j.fertnstert.2011.02.050

Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome

Kathryn G. Ewens, Michelle R. Jones, Wendy Ankener, Douglas R. Stewart, Margrit Urbanek, Andrea Dunaif, Richard S. Legro, Angela Chua, Ricardo Azziz, Richard S. Spielman, Mark O. Goodarzi, Jerome F. Strauss

Art

Research output: Contribution to journal › Article

25 Scopus citations

Abstract

Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.

Original language	English (US)
Journal	Fertility and sterility
Volume	95
Issue number	8
DOIs	https://doi.org/10.1016/j.fertnstert.2011.02.050
Publication status	Published - Jun 30 2011

Fingerprint

Keywords

Polycystic ovary syndrome (PCOS)
SNP
transmission disequilibrium test (TDT)

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

Cite this

Ewens, K. G., Jones, M. R., Ankener, W., Stewart, D. R., Urbanek, M., Dunaif, A., ... Strauss, J. F. (2011). Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome. Fertility and sterility, 95(8). https://doi.org/10.1016/j.fertnstert.2011.02.050

Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome. / Ewens, Kathryn G.; Jones, Michelle R.; Ankener, Wendy; Stewart, Douglas R.; Urbanek, Margrit; Dunaif, Andrea; Legro, Richard S.; Chua, Angela; Azziz, Ricardo; Spielman, Richard S.; Goodarzi, Mark O.; Strauss, Jerome F.

In: Fertility and sterility, Vol. 95, No. 8, 30.06.2011.

Research output: Contribution to journal › Article

Ewens, Kathryn G. ; Jones, Michelle R. ; Ankener, Wendy ; Stewart, Douglas R. ; Urbanek, Margrit ; Dunaif, Andrea ; Legro, Richard S. ; Chua, Angela ; Azziz, Ricardo ; Spielman, Richard S. ; Goodarzi, Mark O. ; Strauss, Jerome F. / Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome. In: Fertility and sterility. 2011 ; Vol. 95, No. 8.

@article{237478547f77449eba467fbdbc4cf6cb,

title = "Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome",

abstract = "Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.",

keywords = "Polycystic ovary syndrome (PCOS), SNP, transmission disequilibrium test (TDT)",

author = "Ewens, {Kathryn G.} and Jones, {Michelle R.} and Wendy Ankener and Stewart, {Douglas R.} and Margrit Urbanek and Andrea Dunaif and Legro, {Richard S.} and Angela Chua and Ricardo Azziz and Spielman, {Richard S.} and Goodarzi, {Mark O.} and Strauss, {Jerome F.}",

year = "2011",

month = "6",

day = "30",

doi = "10.1016/j.fertnstert.2011.02.050",

language = "English (US)",

volume = "95",

journal = "Fertility and Sterility",

issn = "0015-0282",

publisher = "Elsevier Inc.",

number = "8",

}

TY - JOUR

T1 - Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome

AU - Ewens, Kathryn G.

AU - Jones, Michelle R.

AU - Ankener, Wendy

AU - Stewart, Douglas R.

AU - Urbanek, Margrit

AU - Dunaif, Andrea

AU - Legro, Richard S.

AU - Chua, Angela

AU - Azziz, Ricardo

AU - Spielman, Richard S.

AU - Goodarzi, Mark O.

AU - Strauss, Jerome F.

PY - 2011/6/30

Y1 - 2011/6/30

N2 - Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.

AB - Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.

KW - Polycystic ovary syndrome (PCOS)

KW - SNP

KW - transmission disequilibrium test (TDT)

UR - http://www.scopus.com/inward/record.url?scp=79959741221&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959741221&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2011.02.050

DO - 10.1016/j.fertnstert.2011.02.050

M3 - Article

C2 - 21444075

AN - SCOPUS:79959741221

VL - 95

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 8

ER -

Access to Document

10.1016/j.fertnstert.2011.02.050