Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome

Kathryn G. Ewens; Michelle R. Jones; Wendy Ankener; Douglas R. Stewart; Margrit Urbanek; Andrea Dunaif; Richard S. Legro; Angela Chua; Ricardo Azziz; Richard S. Spielman; Mark O. Goodarzi; Jerome F. Strauss

doi:10.1016/j.fertnstert.2011.02.050

Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome

Kathryn G. Ewens, Michelle R. Jones, Wendy Ankener, Douglas R. Stewart, Margrit Urbanek, Andrea Dunaif, Richard S. Legro, Angela Chua, Ricardo Azziz, Richard S. Spielman, Mark O. Goodarzi, Jerome F. Strauss

Art

Research output: Contribution to journal › Article

25 Scopus citations

Abstract

Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.

Original language	English (US)
Journal	Fertility and sterility
Volume	95
Issue number	8
DOIs	https://doi.org/10.1016/j.fertnstert.2011.02.050
State	Published - Jun 30 2011

Keywords

Polycystic ovary syndrome (PCOS)
SNP
transmission disequilibrium test (TDT)

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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10.1016/j.fertnstert.2011.02.050

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Ewens, K. G., Jones, M. R., Ankener, W., Stewart, D. R., Urbanek, M., Dunaif, A., Legro, R. S., Chua, A., Azziz, R., Spielman, R. S., Goodarzi, M. O., & Strauss, J. F. (2011). Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome. Fertility and sterility, 95(8). https://doi.org/10.1016/j.fertnstert.2011.02.050

Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome. / Ewens, Kathryn G.; Jones, Michelle R.; Ankener, Wendy; Stewart, Douglas R.; Urbanek, Margrit; Dunaif, Andrea; Legro, Richard S.; Chua, Angela; Azziz, Ricardo; Spielman, Richard S.; Goodarzi, Mark O.; Strauss, Jerome F.

In: Fertility and sterility, Vol. 95, No. 8, 30.06.2011.

Research output: Contribution to journal › Article

Ewens, Kathryn G. ; Jones, Michelle R. ; Ankener, Wendy ; Stewart, Douglas R. ; Urbanek, Margrit ; Dunaif, Andrea ; Legro, Richard S. ; Chua, Angela ; Azziz, Ricardo ; Spielman, Richard S. ; Goodarzi, Mark O. ; Strauss, Jerome F. / Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome. In: Fertility and sterility. 2011 ; Vol. 95, No. 8.

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