Type I diabetes in an adolescent with common variable immunodeficiency

John E. Moffitt, Margaret Frank Guill, Mary Sue Leffell, Edwin W. Ades, C. Lynne Burek, Steven A. Lobel, William H. Hoffman

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A male adolescent with common variable immunodeficiency developed type I diabetes approximately 1 year after the initiation of immunoglobulin therapy. Immunologic evaluation revealed decreased numbers of T cells and an intrinsic B cell defect in immunoglobulin production. Lymphocytes from the patient failed to generate normal suppressor activity. There were no insulin or islet cell antibodies present in the patient's serum or in the commercial immunoglobulin preparations he received. The panent's HLA phenotype included HLA-DR3 and 4, placing him genetically at high risk for type I diabetes.

Original languageEnglish (US)
Pages (from-to)191-196
Number of pages6
JournalThe Journal of allergy and clinical immunology
Volume84
Issue number2
DOIs
StatePublished - Jan 1 1989

Fingerprint

Common Variable Immunodeficiency
Type 1 Diabetes Mellitus
Immunoglobulins
HLA-DR3 Antigen
Passive Immunization
B-Lymphocytes
Lymphocytes
Insulin
T-Lymphocytes
Phenotype
Serum
islet cell antibody

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Moffitt, J. E., Guill, M. F., Leffell, M. S., Ades, E. W., Burek, C. L., Lobel, S. A., & Hoffman, W. H. (1989). Type I diabetes in an adolescent with common variable immunodeficiency. The Journal of allergy and clinical immunology, 84(2), 191-196. https://doi.org/10.1016/0091-6749(89)90324-2

Type I diabetes in an adolescent with common variable immunodeficiency. / Moffitt, John E.; Guill, Margaret Frank; Leffell, Mary Sue; Ades, Edwin W.; Burek, C. Lynne; Lobel, Steven A.; Hoffman, William H.

In: The Journal of allergy and clinical immunology, Vol. 84, No. 2, 01.01.1989, p. 191-196.

Research output: Contribution to journalArticle

Moffitt, JE, Guill, MF, Leffell, MS, Ades, EW, Burek, CL, Lobel, SA & Hoffman, WH 1989, 'Type I diabetes in an adolescent with common variable immunodeficiency', The Journal of allergy and clinical immunology, vol. 84, no. 2, pp. 191-196. https://doi.org/10.1016/0091-6749(89)90324-2
Moffitt, John E. ; Guill, Margaret Frank ; Leffell, Mary Sue ; Ades, Edwin W. ; Burek, C. Lynne ; Lobel, Steven A. ; Hoffman, William H. / Type I diabetes in an adolescent with common variable immunodeficiency. In: The Journal of allergy and clinical immunology. 1989 ; Vol. 84, No. 2. pp. 191-196.
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