Tyrosine phosphorylation and synapse formation at the neuromuscular junction

Lin Mei, Jutong Si

Research output: Contribution to journalShort survey

11 Scopus citations

Abstract

Protein tyrosine phosphorylation is prevalent throughout the nervous system. It has been implicated to play an important role in the development and maintenance of neuronal functions. In the past few years significant advances have been made in our understanding of the molecular mechanisms of synapse formation and synaptic plasticity. Protein tyrosine phosphorylation appears to be important in the neuron-induced synthesis of the nicotinic acetylcholine receptor and aggregation of synaptic proteins at the neuromuscular junction during development. In addition, protein tyrosine phosphorylation may regulate the ion channel activity of the nicotinic acetylcholine receptor.

Original languageEnglish (US)
Pages (from-to)1459-1466
Number of pages8
JournalLife sciences
Volume57
Issue number16
DOIs
StatePublished - Sep 8 1995

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Keywords

  • kinase
  • phosphatase
  • phosphorylation
  • synapse
  • tyrosine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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