Ultrasonographic assessment of amniotic fluid does not reflect actual amniotic fluid volume

S. P. Chauhan, E. F. Magann, J. C. Morrison, N. S. Whirworth, N. W. Hendrix, Lawrence D Devoe, R. V. Wade

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

OBJECTIVE: Our objective was to compare the ability of two methods of amniotic fluid assessment (two-diameter amniotic fluid pocket versus the amniotic fluid index) to predict oligohydramnios (actual amniotic fluid volume <500 ml) or polyhydramnios (actual amniotic fluid volume >1500 ml). STUDY DESIGN: The amniotic fluid index and the two-diameter amniotic fluid Docket were assessed before amniocentesis and determination of amniotic fluid volume with the dye (aminohippurate sodium)-dilution technique. To assess the detection of either oligohydramnios or polyhydramnios, the areas under the receiver-operator characteristic curves (±SE) were estimated by the point- to-point trapezoidal method of integration. Prediction limits were calculated by regression analysis of amniotic fluid index or two-diameter amniotic fluid pocket versus actual amniotic fluid volume and determination of 95th percentile ranges for amniotic fluid volume. RESULTS: We studied 144 patients with a mean (±SD) gestational age of 31.7 ± 5.5 weeks; mean (±SD) amniotic fluid index and two-diameter amniotic fluid pocket were 12.6 ± 6.1 cm and 21.2 ± 18.4 cm2, respectively. Mean (±SD) actual amniotic fluid volume was 722 ± 735 ml (range 101 to 4318 ml). The areas under the four receiver- operator characteristic curves were not significantly different from the nondiagnostic line (p < 0.05). Regression slopes (r values) for amniotic fluid index and two-diameter amniotic fluid pocket versus actual amniotic fluid volume were 0.34 and 0.23, respectively. Calculation of the prediction limit for 95% confidence that oligohydramnios is absent requires that the amniotic fluid index be 30 cm and the two-dimension amniotic fluid Docket be 90 cm2, both thresholds of which are currently considered to represent clinical polyhydramnios. CONCLUSIONS: Both amniotic fluid index and two- dimension amniotic fluid pocket appear to be inaccurate predictors of actual oligohydramnios or polyhydramnios when compared with dye-dilution calculations of actual amniotic fluid volume.

Original languageEnglish (US)
Pages (from-to)291-297
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume177
Issue number2
DOIs
StatePublished - Jan 1 1997

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Amniotic Fluid
Oligohydramnios
Polyhydramnios
Coloring Agents
p-Aminohippuric Acid
Indicator Dilution Techniques
Amniocentesis

Keywords

  • Amniotic fluid index
  • Amniotic fluid volume

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Ultrasonographic assessment of amniotic fluid does not reflect actual amniotic fluid volume. / Chauhan, S. P.; Magann, E. F.; Morrison, J. C.; Whirworth, N. S.; Hendrix, N. W.; Devoe, Lawrence D; Wade, R. V.

In: American Journal of Obstetrics and Gynecology, Vol. 177, No. 2, 01.01.1997, p. 291-297.

Research output: Contribution to journalArticle

Chauhan, S. P. ; Magann, E. F. ; Morrison, J. C. ; Whirworth, N. S. ; Hendrix, N. W. ; Devoe, Lawrence D ; Wade, R. V. / Ultrasonographic assessment of amniotic fluid does not reflect actual amniotic fluid volume. In: American Journal of Obstetrics and Gynecology. 1997 ; Vol. 177, No. 2. pp. 291-297.
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AU - Magann, E. F.

AU - Morrison, J. C.

AU - Whirworth, N. S.

AU - Hendrix, N. W.

AU - Devoe, Lawrence D

AU - Wade, R. V.

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N2 - OBJECTIVE: Our objective was to compare the ability of two methods of amniotic fluid assessment (two-diameter amniotic fluid pocket versus the amniotic fluid index) to predict oligohydramnios (actual amniotic fluid volume <500 ml) or polyhydramnios (actual amniotic fluid volume >1500 ml). STUDY DESIGN: The amniotic fluid index and the two-diameter amniotic fluid Docket were assessed before amniocentesis and determination of amniotic fluid volume with the dye (aminohippurate sodium)-dilution technique. To assess the detection of either oligohydramnios or polyhydramnios, the areas under the receiver-operator characteristic curves (±SE) were estimated by the point- to-point trapezoidal method of integration. Prediction limits were calculated by regression analysis of amniotic fluid index or two-diameter amniotic fluid pocket versus actual amniotic fluid volume and determination of 95th percentile ranges for amniotic fluid volume. RESULTS: We studied 144 patients with a mean (±SD) gestational age of 31.7 ± 5.5 weeks; mean (±SD) amniotic fluid index and two-diameter amniotic fluid pocket were 12.6 ± 6.1 cm and 21.2 ± 18.4 cm2, respectively. Mean (±SD) actual amniotic fluid volume was 722 ± 735 ml (range 101 to 4318 ml). The areas under the four receiver- operator characteristic curves were not significantly different from the nondiagnostic line (p < 0.05). Regression slopes (r values) for amniotic fluid index and two-diameter amniotic fluid pocket versus actual amniotic fluid volume were 0.34 and 0.23, respectively. Calculation of the prediction limit for 95% confidence that oligohydramnios is absent requires that the amniotic fluid index be 30 cm and the two-dimension amniotic fluid Docket be 90 cm2, both thresholds of which are currently considered to represent clinical polyhydramnios. CONCLUSIONS: Both amniotic fluid index and two- dimension amniotic fluid pocket appear to be inaccurate predictors of actual oligohydramnios or polyhydramnios when compared with dye-dilution calculations of actual amniotic fluid volume.

AB - OBJECTIVE: Our objective was to compare the ability of two methods of amniotic fluid assessment (two-diameter amniotic fluid pocket versus the amniotic fluid index) to predict oligohydramnios (actual amniotic fluid volume <500 ml) or polyhydramnios (actual amniotic fluid volume >1500 ml). STUDY DESIGN: The amniotic fluid index and the two-diameter amniotic fluid Docket were assessed before amniocentesis and determination of amniotic fluid volume with the dye (aminohippurate sodium)-dilution technique. To assess the detection of either oligohydramnios or polyhydramnios, the areas under the receiver-operator characteristic curves (±SE) were estimated by the point- to-point trapezoidal method of integration. Prediction limits were calculated by regression analysis of amniotic fluid index or two-diameter amniotic fluid pocket versus actual amniotic fluid volume and determination of 95th percentile ranges for amniotic fluid volume. RESULTS: We studied 144 patients with a mean (±SD) gestational age of 31.7 ± 5.5 weeks; mean (±SD) amniotic fluid index and two-diameter amniotic fluid pocket were 12.6 ± 6.1 cm and 21.2 ± 18.4 cm2, respectively. Mean (±SD) actual amniotic fluid volume was 722 ± 735 ml (range 101 to 4318 ml). The areas under the four receiver- operator characteristic curves were not significantly different from the nondiagnostic line (p < 0.05). Regression slopes (r values) for amniotic fluid index and two-diameter amniotic fluid pocket versus actual amniotic fluid volume were 0.34 and 0.23, respectively. Calculation of the prediction limit for 95% confidence that oligohydramnios is absent requires that the amniotic fluid index be 30 cm and the two-dimension amniotic fluid Docket be 90 cm2, both thresholds of which are currently considered to represent clinical polyhydramnios. CONCLUSIONS: Both amniotic fluid index and two- dimension amniotic fluid pocket appear to be inaccurate predictors of actual oligohydramnios or polyhydramnios when compared with dye-dilution calculations of actual amniotic fluid volume.

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