Unaltered pulmonary capillary surface area in the presence of changing arterial resistance

Lyle E. Fisher, Attila Cziraki, Curt M. Steinhart, John D. Catravas

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We hypothesized that capillary recruitment may not be solely dependent on extracapillary factors. To test this hypothesis, rabbits were anesthetized and placed on total cardiac bypass at a constant, physiological pulmonary blood flow. Vascular occlusion techniques were combined with measurement of the transpulmonary metabolism of an angiotensin-converting enzyme substrate, allowing the concomitant assessment of changes in segmental resistances and dynamically perfused capillary surface area. Intra-arterial serotonin infusion increased upstream pulmonary vascular resistances without affecting dynamically perfused capillary surface area. Intra-arterial isoproterenol infusion diminished serotonin-induced increased upstream resistances, also without affecting capillary surface area. These findings support the hypothesis that pulmonary capillary recruitment may not be solely dependent on extracapillary factors.

Original languageEnglish (US)
Pages (from-to)L264-L269
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume274
Issue number2 18-2
DOIs
StatePublished - 1998

Keywords

  • Capillary recruitment
  • Isoproterenol
  • Pulmonary circulation
  • Pulmonary hypertension
  • Rabbit
  • Serotonin

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Physiology (medical)
  • Cell Biology

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