Underappreciated delayed late complication of adult brain irradiation: Development of cerebral cavernous malformations

Sajeel Chowdhary, Andrew Sloan, Amyn M. Rojiani, Marc Chamberlain

Research output: Contribution to journalArticle

Abstract

Background: Cerebral cavernous malformations (CCM) are an uncommon delayed late complication of brain radiotherapy in adults. Aim: Describe an adult treated for a malignant glioma with chemotherapy and radiotherapy who subsequently presented with multiple CCM. Methods: Case report and literature review of CCM. Results: Multiple CCM were discovered in an adult following presentation with a symptomatic intracranial hemorrhage. Conclusion: The occurrence of CCM is an unusual delayed late radiation side effect following treatment of CNS tumors. Gradient echo MRI should be considered as a standard sequence in patients with previously treated brain tumors.

Original languageEnglish (US)
Pages (from-to)673-676
Number of pages4
JournalTherapy
Volume4
Issue number5
DOIs
StatePublished - Sep 1 2007
Externally publishedYes

Keywords

  • Cerebral cavernous malformation
  • Complication of brain radiotherapy

ASJC Scopus subject areas

  • Pharmacology (medical)

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