Underappreciated delayed late complication of adult brain irradiation: Development of cerebral cavernous malformations

Sajeel Chowdhary; Andrew Sloan; Amyn M. Rojiani; Marc Chamberlain

doi:10.2217/14750708.4.5.673

Underappreciated delayed late complication of adult brain irradiation: Development of cerebral cavernous malformations

Sajeel Chowdhary, Andrew Sloan, Amyn M. Rojiani, Marc Chamberlain

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Cerebral cavernous malformations (CCM) are an uncommon delayed late complication of brain radiotherapy in adults. Aim: Describe an adult treated for a malignant glioma with chemotherapy and radiotherapy who subsequently presented with multiple CCM. Methods: Case report and literature review of CCM. Results: Multiple CCM were discovered in an adult following presentation with a symptomatic intracranial hemorrhage. Conclusion: The occurrence of CCM is an unusual delayed late radiation side effect following treatment of CNS tumors. Gradient echo MRI should be considered as a standard sequence in patients with previously treated brain tumors.

Original language	English (US)
Pages (from-to)	673-676
Number of pages	4
Journal	Therapy
Volume	4
Issue number	5
DOIs	https://doi.org/10.2217/14750708.4.5.673
State	Published - Sep 1 2007
Externally published	Yes

Keywords

Cerebral cavernous malformation
Complication of brain radiotherapy

ASJC Scopus subject areas

Pharmacology (medical)

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10.2217/14750708.4.5.673

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title = "Underappreciated delayed late complication of adult brain irradiation: Development of cerebral cavernous malformations",

abstract = "Background: Cerebral cavernous malformations (CCM) are an uncommon delayed late complication of brain radiotherapy in adults. Aim: Describe an adult treated for a malignant glioma with chemotherapy and radiotherapy who subsequently presented with multiple CCM. Methods: Case report and literature review of CCM. Results: Multiple CCM were discovered in an adult following presentation with a symptomatic intracranial hemorrhage. Conclusion: The occurrence of CCM is an unusual delayed late radiation side effect following treatment of CNS tumors. Gradient echo MRI should be considered as a standard sequence in patients with previously treated brain tumors.",

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AU - Chowdhary, Sajeel

AU - Sloan, Andrew

AU - Rojiani, Amyn M.

AU - Chamberlain, Marc

PY - 2007/9/1

Y1 - 2007/9/1

N2 - Background: Cerebral cavernous malformations (CCM) are an uncommon delayed late complication of brain radiotherapy in adults. Aim: Describe an adult treated for a malignant glioma with chemotherapy and radiotherapy who subsequently presented with multiple CCM. Methods: Case report and literature review of CCM. Results: Multiple CCM were discovered in an adult following presentation with a symptomatic intracranial hemorrhage. Conclusion: The occurrence of CCM is an unusual delayed late radiation side effect following treatment of CNS tumors. Gradient echo MRI should be considered as a standard sequence in patients with previously treated brain tumors.

AB - Background: Cerebral cavernous malformations (CCM) are an uncommon delayed late complication of brain radiotherapy in adults. Aim: Describe an adult treated for a malignant glioma with chemotherapy and radiotherapy who subsequently presented with multiple CCM. Methods: Case report and literature review of CCM. Results: Multiple CCM were discovered in an adult following presentation with a symptomatic intracranial hemorrhage. Conclusion: The occurrence of CCM is an unusual delayed late radiation side effect following treatment of CNS tumors. Gradient echo MRI should be considered as a standard sequence in patients with previously treated brain tumors.

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