TY - JOUR
T1 - Understanding the biologic therapies of probiotics, prebiotics, and synbiotics
T2 - Exploring current evidence for use in premature infants for the prevention of necrotizing enterocolitis
AU - Asmerom, Mussie
AU - Crowe, Lindsay
AU - Marin, Terri
N1 - Publisher Copyright:
Copyright © 2015 Wolters Kluwer Health, Inc.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Necrotizing enterocolitis remains a significant cause of morbidity and mortality in very low-birth-weight infants (<1500 g), with current preventive strategies unclear. Scientific evidence has recently emerged, suggesting that probiotics, prebiotics, and synbiotics may effectively and safely alter the premature intestinal microbiota, enhancing a deficient innate immune response and maturing the intestinal barrier to prevent necrotizing enterocolitis development. Currently, formal recommendations do not support routine use of these dietary supplementations for premature infants. Here, we examine how probiotic, prebiotic, and synbiotic preparations physiologically alter the underdeveloped intestinal microbial environment to potentially reduce necrotizing enterocolitis incidence and discuss current evidence that has examined safety and efficacy factors potentially supporting routine use among the premature infant population.
AB - Necrotizing enterocolitis remains a significant cause of morbidity and mortality in very low-birth-weight infants (<1500 g), with current preventive strategies unclear. Scientific evidence has recently emerged, suggesting that probiotics, prebiotics, and synbiotics may effectively and safely alter the premature intestinal microbiota, enhancing a deficient innate immune response and maturing the intestinal barrier to prevent necrotizing enterocolitis development. Currently, formal recommendations do not support routine use of these dietary supplementations for premature infants. Here, we examine how probiotic, prebiotic, and synbiotic preparations physiologically alter the underdeveloped intestinal microbial environment to potentially reduce necrotizing enterocolitis incidence and discuss current evidence that has examined safety and efficacy factors potentially supporting routine use among the premature infant population.
KW - Microbiome
KW - Necrotizing enterocolitis
KW - Prebiotic
KW - Prematurity
KW - Probiotic
KW - Synbiotic
UR - http://www.scopus.com/inward/record.url?scp=84942574468&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84942574468&partnerID=8YFLogxK
U2 - 10.1097/JPN.0000000000000120
DO - 10.1097/JPN.0000000000000120
M3 - Article
C2 - 26218817
AN - SCOPUS:84942574468
SN - 0893-2190
VL - 29
SP - 240
EP - 247
JO - Journal of Perinatal and Neonatal Nursing
JF - Journal of Perinatal and Neonatal Nursing
IS - 3
ER -