Unnecessary workup of asymptomatic neonates in the era of Group B streptococcus prophylaxis

Brad Buckler, Jason Bell, Ralph Sams, William E Cagle, Sue Anne Bell, Carla Allen, Don Sutherland, Jatinder J Bhatia

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Asymptomatic term neonates born to mothers who are Group B Streptococcus (GBS) unknown or GBS positive but inadequately treated prior to delivery do not require invasive laboratory evaluation. We conducted a retrospective cohort study of mother/baby dyads born from January 1, 2005 until September 30, 2007 at the Medical College of Georgia. Their current protocol is to obtain a Complete Blood Count with Differential (CBC with D), Blood Culture (BC), and C-reactive protein (CRP) after birth. Mother/baby dyads (n=242) that met inclusion criteria were reviewed. Of these 242 babies 25 (10) were started on antibiotics after the initial lab values were known. None of the blood cultures were positive and the CRP's were normal. The 2002 GBS guidelines call for laboratory evaluation of at-risk neonates, but the workup of these babies is not only costly, it does not provide any advantage over old fashioned clinical observation for the evaluation and treatment of early onset GBS sepsis.

Original languageEnglish (US)
Article number369654
JournalInfectious Diseases in Obstetrics and Gynecology
Volume2010
DOIs
StatePublished - Oct 18 2010

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Streptococcus agalactiae
Blood Cell Count
C-Reactive Protein
Sepsis
Cohort Studies
Retrospective Studies
Observation
Parturition
Guidelines
Anti-Bacterial Agents
Blood Culture

ASJC Scopus subject areas

  • Dermatology
  • Obstetrics and Gynecology
  • Infectious Diseases

Cite this

Unnecessary workup of asymptomatic neonates in the era of Group B streptococcus prophylaxis. / Buckler, Brad; Bell, Jason; Sams, Ralph; Cagle, William E; Bell, Sue Anne; Allen, Carla; Sutherland, Don; Bhatia, Jatinder J.

In: Infectious Diseases in Obstetrics and Gynecology, Vol. 2010, 369654, 18.10.2010.

Research output: Contribution to journalArticle

Buckler, Brad ; Bell, Jason ; Sams, Ralph ; Cagle, William E ; Bell, Sue Anne ; Allen, Carla ; Sutherland, Don ; Bhatia, Jatinder J. / Unnecessary workup of asymptomatic neonates in the era of Group B streptococcus prophylaxis. In: Infectious Diseases in Obstetrics and Gynecology. 2010 ; Vol. 2010.
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