Unusual encephalopathy after acute chest syndrome in sickle cell disease: Acute necrotizing encephalitis

Ki Hyeong Lee, Virgil C. McKie, Elizabeth Sekul, Robert J. Adams, Fenwick T Nichols

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Stroke is the most common neurologic complication of sickle cell disease. Acute chest syndrome (ACS) is a known risk factor for stroke in this population. Two patients (a 12-year-old boy and a 6-year-old girl) developed acute change of mental status and focal neurologic signs during episodes of ACS. The clinical and radiologic findings were compatible with acute necrotizing encephalitis, a variant of acute demyelinating encephalomyelitis. Patients with acute neurologic deterioration in conjunction with ACS should be evaluated thoroughly for other causes of central nervous system disease including infectious/parainfectious processes as well as stroke.

Original languageEnglish (US)
Pages (from-to)585-588
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Volume24
Issue number7
DOIs
StatePublished - Oct 1 2002

Keywords

  • Acute chest syndrome
  • Acute necrotizing encephalopathy
  • Mycoplasma pneumonia
  • Sickle cell anemia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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