Update on G-protein polymorphisms in hypertension

Haidong Zhu, Xiaoling Wang, Yanhui Lu, Joseph Poola, Zamena Momin, Gregory A Harshfield, Harold Snieder, Yanbin Dong

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

The classic candidate gene approach continues to be the most prevalent tool in the search for the genetic basis of essential hypertension. With the list of candidate genes for this disorder steadily increasing, the pertussis toxin-sensitive inhibitory G protein (G1) protein β3 subunit (GNB3) gene has remained "sizzling," challenging the domination of the renin-angiotensin system. Is the genetic variability of GNB3 a causative factor underlying the pathogenesis of essential hypertension? Is the "functional" polymorphism, C825T, only "another" of the countless single nucleotide polymorphisms (SNP) for this disorder after all? As such, does its presence merely reinforce our confidence that essential hypertension is indeed polygenic? Should the C825T polymorphism be used in clinical practice and individualized antihypertensive treatment? Currently, there are still more questions than answers. In this review, in conjunction with our own research, we bring readers up to date on the latest developments of GNB3 polymorphisms in the field of hypertension.

Original languageEnglish (US)
Pages (from-to)23-29
Number of pages7
JournalCurrent Hypertension Reports
Volume8
Issue number1
DOIs
StatePublished - Apr 1 2006

Fingerprint

GTP-Binding Proteins
Hypertension
Genes
Pertussis Toxin
Protein Subunits
Renin-Angiotensin System
Antihypertensive Agents
Single Nucleotide Polymorphism
Research
Essential Hypertension

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Update on G-protein polymorphisms in hypertension. / Zhu, Haidong; Wang, Xiaoling; Lu, Yanhui; Poola, Joseph; Momin, Zamena; Harshfield, Gregory A; Snieder, Harold; Dong, Yanbin.

In: Current Hypertension Reports, Vol. 8, No. 1, 01.04.2006, p. 23-29.

Research output: Contribution to journalReview article

Zhu, Haidong ; Wang, Xiaoling ; Lu, Yanhui ; Poola, Joseph ; Momin, Zamena ; Harshfield, Gregory A ; Snieder, Harold ; Dong, Yanbin. / Update on G-protein polymorphisms in hypertension. In: Current Hypertension Reports. 2006 ; Vol. 8, No. 1. pp. 23-29.
@article{5cf722ec158c413690557b2d88786ca8,
title = "Update on G-protein polymorphisms in hypertension",
abstract = "The classic candidate gene approach continues to be the most prevalent tool in the search for the genetic basis of essential hypertension. With the list of candidate genes for this disorder steadily increasing, the pertussis toxin-sensitive inhibitory G protein (G1) protein β3 subunit (GNB3) gene has remained {"}sizzling,{"} challenging the domination of the renin-angiotensin system. Is the genetic variability of GNB3 a causative factor underlying the pathogenesis of essential hypertension? Is the {"}functional{"} polymorphism, C825T, only {"}another{"} of the countless single nucleotide polymorphisms (SNP) for this disorder after all? As such, does its presence merely reinforce our confidence that essential hypertension is indeed polygenic? Should the C825T polymorphism be used in clinical practice and individualized antihypertensive treatment? Currently, there are still more questions than answers. In this review, in conjunction with our own research, we bring readers up to date on the latest developments of GNB3 polymorphisms in the field of hypertension.",
author = "Haidong Zhu and Xiaoling Wang and Yanhui Lu and Joseph Poola and Zamena Momin and Harshfield, {Gregory A} and Harold Snieder and Yanbin Dong",
year = "2006",
month = "4",
day = "1",
doi = "10.1007/s11906-006-0037-4",
language = "English (US)",
volume = "8",
pages = "23--29",
journal = "Current Hypertension Reports",
issn = "1522-6417",
publisher = "Current Medicine Group",
number = "1",

}

TY - JOUR

T1 - Update on G-protein polymorphisms in hypertension

AU - Zhu, Haidong

AU - Wang, Xiaoling

AU - Lu, Yanhui

AU - Poola, Joseph

AU - Momin, Zamena

AU - Harshfield, Gregory A

AU - Snieder, Harold

AU - Dong, Yanbin

PY - 2006/4/1

Y1 - 2006/4/1

N2 - The classic candidate gene approach continues to be the most prevalent tool in the search for the genetic basis of essential hypertension. With the list of candidate genes for this disorder steadily increasing, the pertussis toxin-sensitive inhibitory G protein (G1) protein β3 subunit (GNB3) gene has remained "sizzling," challenging the domination of the renin-angiotensin system. Is the genetic variability of GNB3 a causative factor underlying the pathogenesis of essential hypertension? Is the "functional" polymorphism, C825T, only "another" of the countless single nucleotide polymorphisms (SNP) for this disorder after all? As such, does its presence merely reinforce our confidence that essential hypertension is indeed polygenic? Should the C825T polymorphism be used in clinical practice and individualized antihypertensive treatment? Currently, there are still more questions than answers. In this review, in conjunction with our own research, we bring readers up to date on the latest developments of GNB3 polymorphisms in the field of hypertension.

AB - The classic candidate gene approach continues to be the most prevalent tool in the search for the genetic basis of essential hypertension. With the list of candidate genes for this disorder steadily increasing, the pertussis toxin-sensitive inhibitory G protein (G1) protein β3 subunit (GNB3) gene has remained "sizzling," challenging the domination of the renin-angiotensin system. Is the genetic variability of GNB3 a causative factor underlying the pathogenesis of essential hypertension? Is the "functional" polymorphism, C825T, only "another" of the countless single nucleotide polymorphisms (SNP) for this disorder after all? As such, does its presence merely reinforce our confidence that essential hypertension is indeed polygenic? Should the C825T polymorphism be used in clinical practice and individualized antihypertensive treatment? Currently, there are still more questions than answers. In this review, in conjunction with our own research, we bring readers up to date on the latest developments of GNB3 polymorphisms in the field of hypertension.

UR - http://www.scopus.com/inward/record.url?scp=33646047704&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646047704&partnerID=8YFLogxK

U2 - 10.1007/s11906-006-0037-4

DO - 10.1007/s11906-006-0037-4

M3 - Review article

C2 - 16600156

AN - SCOPUS:33646047704

VL - 8

SP - 23

EP - 29

JO - Current Hypertension Reports

JF - Current Hypertension Reports

SN - 1522-6417

IS - 1

ER -