Update on the Role of Glucocorticoid Signaling in Osteoblasts and Bone Marrow Adipocytes During Aging

Husam Bensreti; Dima W. Alhamad; Alejandro Marrero Gonzalez; Manuel Pizarro-Mondesir; Wendy B. Bollag; Carlos M. Isales; Meghan E. McGee-Lawrence

doi:10.1007/s11914-022-00772-5

Update on the Role of Glucocorticoid Signaling in Osteoblasts and Bone Marrow Adipocytes During Aging

Husam Bensreti, Dima W. Alhamad, Alejandro Marrero Gonzalez, Manuel Pizarro-Mondesir, Wendy B. Bollag, Carlos M. Isales, Meghan E. McGee-Lawrence

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Purpose of Review: Bone marrow adipose tissue (BMAT) in the skeleton likely plays a variety of physiological and pathophysiological roles that are not yet fully understood. In elucidating the complex relationship between bone and BMAT, glucocorticoids (GCs) are positioned to play a key role, as they have been implicated in the differentiation of bone marrow mesenchymal stem cells (BMSCs) between osteogenic and adipogenic lineages. The purpose of this review is to illuminate aspects of both endogenous and exogenous GC signaling, including the influence of GC receptors, in mechanisms of bone aging including relationships to BMAT. Recent Findings: Harmful effects of GCs on bone mass involve several cellular pathways and events that can include BMSC differentiation bias toward adipogenesis and the influence of mature BMAT on bone remodeling through crosstalk. Interestingly, BMAT involvement remains poorly explored in GC-induced osteoporosis and warrants further investigation. Summary: This review provides an update on the current understanding of the role of glucocorticoids in the biology of osteoblasts and bone marrow adipocytes (BMAds).

Original language	English (US)
Pages (from-to)	32-44
Number of pages	13
Journal	Current Osteoporosis Reports
Volume	21
Issue number	1
DOIs	https://doi.org/10.1007/s11914-022-00772-5
State	Published - Feb 2023

Keywords

BMAT
BMAd
BMSC
Dexamethasone
Glucocorticoid
Osteoporosis

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11914-022-00772-5

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title = "Update on the Role of Glucocorticoid Signaling in Osteoblasts and Bone Marrow Adipocytes During Aging",

abstract = "Purpose of Review: Bone marrow adipose tissue (BMAT) in the skeleton likely plays a variety of physiological and pathophysiological roles that are not yet fully understood. In elucidating the complex relationship between bone and BMAT, glucocorticoids (GCs) are positioned to play a key role, as they have been implicated in the differentiation of bone marrow mesenchymal stem cells (BMSCs) between osteogenic and adipogenic lineages. The purpose of this review is to illuminate aspects of both endogenous and exogenous GC signaling, including the influence of GC receptors, in mechanisms of bone aging including relationships to BMAT. Recent Findings: Harmful effects of GCs on bone mass involve several cellular pathways and events that can include BMSC differentiation bias toward adipogenesis and the influence of mature BMAT on bone remodeling through crosstalk. Interestingly, BMAT involvement remains poorly explored in GC-induced osteoporosis and warrants further investigation. Summary: This review provides an update on the current understanding of the role of glucocorticoids in the biology of osteoblasts and bone marrow adipocytes (BMAds).",

keywords = "BMAT, BMAd, BMSC, Dexamethasone, Glucocorticoid, Osteoporosis",

author = "Husam Bensreti and Alhamad, {Dima W.} and Gonzalez, {Alejandro Marrero} and Manuel Pizarro-Mondesir and Bollag, {Wendy B.} and Isales, {Carlos M.} and McGee-Lawrence, {Meghan E.}",

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year = "2023",

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doi = "10.1007/s11914-022-00772-5",

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AU - Bensreti, Husam

AU - Alhamad, Dima W.

AU - Gonzalez, Alejandro Marrero

AU - Pizarro-Mondesir, Manuel

AU - Bollag, Wendy B.

AU - Isales, Carlos M.

AU - McGee-Lawrence, Meghan E.

PY - 2023/2

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N2 - Purpose of Review: Bone marrow adipose tissue (BMAT) in the skeleton likely plays a variety of physiological and pathophysiological roles that are not yet fully understood. In elucidating the complex relationship between bone and BMAT, glucocorticoids (GCs) are positioned to play a key role, as they have been implicated in the differentiation of bone marrow mesenchymal stem cells (BMSCs) between osteogenic and adipogenic lineages. The purpose of this review is to illuminate aspects of both endogenous and exogenous GC signaling, including the influence of GC receptors, in mechanisms of bone aging including relationships to BMAT. Recent Findings: Harmful effects of GCs on bone mass involve several cellular pathways and events that can include BMSC differentiation bias toward adipogenesis and the influence of mature BMAT on bone remodeling through crosstalk. Interestingly, BMAT involvement remains poorly explored in GC-induced osteoporosis and warrants further investigation. Summary: This review provides an update on the current understanding of the role of glucocorticoids in the biology of osteoblasts and bone marrow adipocytes (BMAds).

AB - Purpose of Review: Bone marrow adipose tissue (BMAT) in the skeleton likely plays a variety of physiological and pathophysiological roles that are not yet fully understood. In elucidating the complex relationship between bone and BMAT, glucocorticoids (GCs) are positioned to play a key role, as they have been implicated in the differentiation of bone marrow mesenchymal stem cells (BMSCs) between osteogenic and adipogenic lineages. The purpose of this review is to illuminate aspects of both endogenous and exogenous GC signaling, including the influence of GC receptors, in mechanisms of bone aging including relationships to BMAT. Recent Findings: Harmful effects of GCs on bone mass involve several cellular pathways and events that can include BMSC differentiation bias toward adipogenesis and the influence of mature BMAT on bone remodeling through crosstalk. Interestingly, BMAT involvement remains poorly explored in GC-induced osteoporosis and warrants further investigation. Summary: This review provides an update on the current understanding of the role of glucocorticoids in the biology of osteoblasts and bone marrow adipocytes (BMAds).

KW - BMAT

KW - BMAd

KW - BMSC

KW - Dexamethasone

KW - Glucocorticoid

KW - Osteoporosis

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Update on the Role of Glucocorticoid Signaling in Osteoblasts and Bone Marrow Adipocytes During Aging

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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