Upregulation of thrombospondin-1(TSP-1) and its binding partners, CD36 and CD47, in sporadic inclusion body myositis

Mohammad Salajegheh, Raghavan Raju, Jens Schmidt, Marinos C. Dalakas

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The TSP1/CD36/CD47-complex is involved in T cell expansion and inflammatory responses to β-amyloid, both relevant to IBM. We report on the mRNA and protein expression of TSP1/ CD36 /CD47-complex in IBM muscles and in human myoblasts after cytokine stimulation. The TSP1/CD36 /CD47 was upregulated in IBM. TSP1 immunolocalized to the connective tissue contiguous to inflammation and CD36/CD47 on the myofibers and CD8+ cells. Further, TNF-α upregulated the production of TSP1 and CD47 by myoblasts. The TSP-complex is another inflammatory mediator associated with chronic inflammation in IBM that may perpetuate the immune responses to local antigens in response to TNF-α.

Original languageEnglish (US)
Pages (from-to)166-174
Number of pages9
JournalJournal of Neuroimmunology
Volume187
Issue number1-2
DOIs
StatePublished - Jul 1 2007
Externally publishedYes

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Keywords

  • Amyloid
  • CD36
  • CD47
  • Dermatomyositis
  • Inclusion body myositis
  • Thrombospondin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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