Upregulation of thrombospondin-1(TSP-1) and its binding partners, CD36 and CD47, in sporadic inclusion body myositis

Mohammad Salajegheh; Raghavan Raju; Jens Schmidt; Marinos C. Dalakas

doi:10.1016/j.jneuroim.2007.04.022

Upregulation of thrombospondin-1(TSP-1) and its binding partners, CD36 and CD47, in sporadic inclusion body myositis

Mohammad Salajegheh, Raghavan Raju, Jens Schmidt, Marinos C. Dalakas

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The TSP1/CD36/CD47-complex is involved in T cell expansion and inflammatory responses to β-amyloid, both relevant to IBM. We report on the mRNA and protein expression of TSP1/ CD36 /CD47-complex in IBM muscles and in human myoblasts after cytokine stimulation. The TSP1/CD36 /CD47 was upregulated in IBM. TSP1 immunolocalized to the connective tissue contiguous to inflammation and CD36/CD47 on the myofibers and CD8+ cells. Further, TNF-α upregulated the production of TSP1 and CD47 by myoblasts. The TSP-complex is another inflammatory mediator associated with chronic inflammation in IBM that may perpetuate the immune responses to local antigens in response to TNF-α.

Original language	English (US)
Pages (from-to)	166-174
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	187
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2007.04.022
State	Published - Jul 2007
Externally published	Yes

Keywords

Amyloid
CD36
CD47
Dermatomyositis
Inclusion body myositis
Thrombospondin

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2007.04.022

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title = "Upregulation of thrombospondin-1(TSP-1) and its binding partners, CD36 and CD47, in sporadic inclusion body myositis",

abstract = "The TSP1/CD36/CD47-complex is involved in T cell expansion and inflammatory responses to β-amyloid, both relevant to IBM. We report on the mRNA and protein expression of TSP1/ CD36 /CD47-complex in IBM muscles and in human myoblasts after cytokine stimulation. The TSP1/CD36 /CD47 was upregulated in IBM. TSP1 immunolocalized to the connective tissue contiguous to inflammation and CD36/CD47 on the myofibers and CD8+ cells. Further, TNF-α upregulated the production of TSP1 and CD47 by myoblasts. The TSP-complex is another inflammatory mediator associated with chronic inflammation in IBM that may perpetuate the immune responses to local antigens in response to TNF-α.",

keywords = "Amyloid, CD36, CD47, Dermatomyositis, Inclusion body myositis, Thrombospondin",

author = "Mohammad Salajegheh and Raghavan Raju and Jens Schmidt and Dalakas, {Marinos C.}",

note = "Funding Information: This research was supported by the Intramural Research Program of NINDS, NIH. Mohammad Salajegheh thanks the Comprehensive Neuroscience Program (CNP) of The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF) for their financial support. Jens Schmidt was supported by the Deutsche Forschungsgemeinschaft (DFG, Schm 1669/1-1) and the Myositis Association (TMA). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2007",

month = jul,

doi = "10.1016/j.jneuroim.2007.04.022",

language = "English (US)",

volume = "187",

pages = "166--174",

journal = "Journal of Neuroimmunology",

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AU - Salajegheh, Mohammad

AU - Raju, Raghavan

AU - Schmidt, Jens

AU - Dalakas, Marinos C.

N1 - Funding Information: This research was supported by the Intramural Research Program of NINDS, NIH. Mohammad Salajegheh thanks the Comprehensive Neuroscience Program (CNP) of The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF) for their financial support. Jens Schmidt was supported by the Deutsche Forschungsgemeinschaft (DFG, Schm 1669/1-1) and the Myositis Association (TMA). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2007/7

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N2 - The TSP1/CD36/CD47-complex is involved in T cell expansion and inflammatory responses to β-amyloid, both relevant to IBM. We report on the mRNA and protein expression of TSP1/ CD36 /CD47-complex in IBM muscles and in human myoblasts after cytokine stimulation. The TSP1/CD36 /CD47 was upregulated in IBM. TSP1 immunolocalized to the connective tissue contiguous to inflammation and CD36/CD47 on the myofibers and CD8+ cells. Further, TNF-α upregulated the production of TSP1 and CD47 by myoblasts. The TSP-complex is another inflammatory mediator associated with chronic inflammation in IBM that may perpetuate the immune responses to local antigens in response to TNF-α.

AB - The TSP1/CD36/CD47-complex is involved in T cell expansion and inflammatory responses to β-amyloid, both relevant to IBM. We report on the mRNA and protein expression of TSP1/ CD36 /CD47-complex in IBM muscles and in human myoblasts after cytokine stimulation. The TSP1/CD36 /CD47 was upregulated in IBM. TSP1 immunolocalized to the connective tissue contiguous to inflammation and CD36/CD47 on the myofibers and CD8+ cells. Further, TNF-α upregulated the production of TSP1 and CD47 by myoblasts. The TSP-complex is another inflammatory mediator associated with chronic inflammation in IBM that may perpetuate the immune responses to local antigens in response to TNF-α.

KW - Amyloid

KW - CD36

KW - CD47

KW - Dermatomyositis

KW - Inclusion body myositis

KW - Thrombospondin

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Upregulation of thrombospondin-1(TSP-1) and its binding partners, CD36 and CD47, in sporadic inclusion body myositis

Abstract

Keywords

ASJC Scopus subject areas

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