Urinary cytologic findings in patients with benign and malignant adenomatous polyps of the prostatic urethra

Vicki J. Schnadig, Adekunle Adesokan, Durwood Earnest Neal, Zoran Gatalica

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Context. - Urethral adenomatous polyps with prostatic epithelium (also known as benign prostatic epithelial polyps [BPEPs]) are a documented cause of hematuria, dysuria, and hematospermia, conditions that may prompt cytologic evaluation of urine. Design. - The urine cytologic test findings in 5 cases of biopsy-proven BPEPs and in 1 case of prostatic ductal adenocarcinoma (PDA) that presented as a urethral polyp were retrospectively evaluated. Immunocytochemical stain for prostate-specific antigen (PSA), prostatic acid phosphatase (PAP), and high-molecular-weight cytokeratin (34βE12) were used in evaluation of the lesions. Results. - In 4 of 5 cases of BPEPs, clusters of bland columnar cells with uniform, oval nuclei were seen. Positive immunostaining for PSA and PAP confirmed the prostatic origin of the clusters in 2 cases. One urine sample contained abundant goblet cells and extracellular mucin, consistent with intestinal metaplasia coexisting in the bladder biopsy specimen. The urine sample in the fifth case of BPEPs contained no columnar cells. The last case had multiple urine cytologic evaluations that demonstrated PSA-positive, malignant-appearing clusters of columnar cells. A biopsy specimen of the polyps was described as a high-grade prostatic intraepithelial neoplasm in adenomatous polyp. However, in this patient, PDA was diagnosed on transurethral resection of the prostate specimen 4 years after the initial urine cytologic test. Conclusion. - Benign prostatic epithelial polyps should be considered in the differential diagnosis of clusters of columnar cells in urine cytologic testing. Cells with malignant nuclear features should instigate a careful search for a (prostatic) neoplasm, which may present as urethral polyps (eg, PDA). Stains for PSA or PAP are useful adjuncts in differential diagnosis of this condition.

Original languageEnglish (US)
Pages (from-to)1047-1052
Number of pages6
JournalArchives of Pathology and Laboratory Medicine
Volume124
Issue number7
StatePublished - Aug 15 2000

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Adenomatous Polyps
Urethra
Polyps
Urine
Prostate-Specific Antigen
Adenocarcinoma
Biopsy
Differential Diagnosis
Coloring Agents
Hemospermia
Prostatic Intraepithelial Neoplasia
Dysuria
Transurethral Resection of Prostate
Goblet Cells
Metaplasia
Mucins
Hematuria
Keratins
Prostatic Neoplasms
Urinary Bladder

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Urinary cytologic findings in patients with benign and malignant adenomatous polyps of the prostatic urethra. / Schnadig, Vicki J.; Adesokan, Adekunle; Neal, Durwood Earnest; Gatalica, Zoran.

In: Archives of Pathology and Laboratory Medicine, Vol. 124, No. 7, 15.08.2000, p. 1047-1052.

Research output: Contribution to journalArticle

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