Urinary excretion of vasoactive factors are correlated to sodium excretion

Robert W. Jackson; Frank A. Treiber; Gregory A. Harshfield; Jennifer L. Waller; Jennifer S. Pollock; David M. Pollock

doi:10.1016/S0895-7061(01)02169-0

Urinary excretion of vasoactive factors are correlated to sodium excretion

Robert W. Jackson, Frank A. Treiber, Gregory A. Harshfield, Jennifer L. Waller, Jennifer S. Pollock, David M. Pollock

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Background: The relationship between urinary vasoactive factors and sodium excretion has not been adequately addressed in humans. Procedure: Excretion rates of sodium, nitrates/nitrites (NOx), cGMP, and endothelin-1 (ET-1) were measured before and after ingestion of a mixed electrolyte solution (8 oz Gatorade) while undergoing a routine cardiovascular evaluation in a sample of 51 normotensive young adults. Results: Significant correlations were detected for changes in excretion between all four variables, r ranged from 0.50 to 0.86 (P < .001). Correlations were higher in African Americans than white Americans. Conclusions: The association of renal ET-1 and NO activity with sodium excretion supports the hypothesis that these factors play a role in the physiologic response to acute changes in sodium intake, particularly in African Americans.

Original language	English (US)
Pages (from-to)	1003-1006
Number of pages	4
Journal	American journal of hypertension
Volume	14
Issue number	10
DOIs	https://doi.org/10.1016/S0895-7061(01)02169-0
State	Published - 2001

Keywords

Endothelin-1
Ethnicity
Nitric oxide
Renal
Sodium

ASJC Scopus subject areas

Internal Medicine

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10.1016/S0895-7061(01)02169-0

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@article{0d09343680db4397b70cd542ab792d24,

title = "Urinary excretion of vasoactive factors are correlated to sodium excretion",

abstract = "Background: The relationship between urinary vasoactive factors and sodium excretion has not been adequately addressed in humans. Procedure: Excretion rates of sodium, nitrates/nitrites (NOx), cGMP, and endothelin-1 (ET-1) were measured before and after ingestion of a mixed electrolyte solution (8 oz Gatorade) while undergoing a routine cardiovascular evaluation in a sample of 51 normotensive young adults. Results: Significant correlations were detected for changes in excretion between all four variables, r ranged from 0.50 to 0.86 (P < .001). Correlations were higher in African Americans than white Americans. Conclusions: The association of renal ET-1 and NO activity with sodium excretion supports the hypothesis that these factors play a role in the physiologic response to acute changes in sodium intake, particularly in African Americans.",

keywords = "Endothelin-1, Ethnicity, Nitric oxide, Renal, Sodium",

author = "Jackson, {Robert W.} and Treiber, {Frank A.} and Harshfield, {Gregory A.} and Waller, {Jennifer L.} and Pollock, {Jennifer S.} and Pollock, {David M.}",

note = "Funding Information: This study was supported by NHLBI HL 41781 (FAT), HL 35073 (FAT), HL 60653 (JSP, DMP), and Scientist Development Grants of the American Heart Association (JSP, DMP). ",

year = "2001",

doi = "10.1016/S0895-7061(01)02169-0",

language = "English (US)",

volume = "14",

pages = "1003--1006",

journal = "American journal of hypertension",

issn = "0895-7061",

publisher = "Oxford University Press",

number = "10",

}

TY - JOUR

T1 - Urinary excretion of vasoactive factors are correlated to sodium excretion

AU - Jackson, Robert W.

AU - Treiber, Frank A.

AU - Harshfield, Gregory A.

AU - Waller, Jennifer L.

AU - Pollock, Jennifer S.

AU - Pollock, David M.

N1 - Funding Information: This study was supported by NHLBI HL 41781 (FAT), HL 35073 (FAT), HL 60653 (JSP, DMP), and Scientist Development Grants of the American Heart Association (JSP, DMP).

PY - 2001

Y1 - 2001

N2 - Background: The relationship between urinary vasoactive factors and sodium excretion has not been adequately addressed in humans. Procedure: Excretion rates of sodium, nitrates/nitrites (NOx), cGMP, and endothelin-1 (ET-1) were measured before and after ingestion of a mixed electrolyte solution (8 oz Gatorade) while undergoing a routine cardiovascular evaluation in a sample of 51 normotensive young adults. Results: Significant correlations were detected for changes in excretion between all four variables, r ranged from 0.50 to 0.86 (P < .001). Correlations were higher in African Americans than white Americans. Conclusions: The association of renal ET-1 and NO activity with sodium excretion supports the hypothesis that these factors play a role in the physiologic response to acute changes in sodium intake, particularly in African Americans.

AB - Background: The relationship between urinary vasoactive factors and sodium excretion has not been adequately addressed in humans. Procedure: Excretion rates of sodium, nitrates/nitrites (NOx), cGMP, and endothelin-1 (ET-1) were measured before and after ingestion of a mixed electrolyte solution (8 oz Gatorade) while undergoing a routine cardiovascular evaluation in a sample of 51 normotensive young adults. Results: Significant correlations were detected for changes in excretion between all four variables, r ranged from 0.50 to 0.86 (P < .001). Correlations were higher in African Americans than white Americans. Conclusions: The association of renal ET-1 and NO activity with sodium excretion supports the hypothesis that these factors play a role in the physiologic response to acute changes in sodium intake, particularly in African Americans.

KW - Endothelin-1

KW - Ethnicity

KW - Nitric oxide

KW - Renal

KW - Sodium

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U2 - 10.1016/S0895-7061(01)02169-0

DO - 10.1016/S0895-7061(01)02169-0

M3 - Article

C2 - 11710777

AN - SCOPUS:0034775601

SN - 0895-7061

VL - 14

SP - 1003

EP - 1006

JO - American journal of hypertension

JF - American journal of hypertension

IS - 10

ER -

Urinary excretion of vasoactive factors are correlated to sodium excretion

Abstract

Keywords

ASJC Scopus subject areas

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