Urinary paranitrophenol, a metabolite of methyl parathion, in thai farmer and child populations

Parinya Panuwet, Tippawan Prapamontol, Somporn Chantara, Prasak Thavornyuthikarn, Roberto Bravo, Paula Restrepo, Robert D. Walker, Bryan L Williams, Larry L. Needham, Dana B. Barr

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Human exposure to methyl parathion can be assessed by measuring the concentration of its metabolite paranitrophenol (PNP) in urine. Our biologic monitoring study in Chiang Mai, Thailand, measured PNP and dialkylphosphate metabolites (i.e., dimethylphosphate [DMP] and dimethylthiophosphate [DMTP]) of methyl parathion in urine samples collected from 136 farmers (age 20 to 65 years) and 306 school children (age 10 to 15 years) in 2006. Participants came from two topographically different areas: one was colder and mountainous, whereas the other was alluvial with climate fluctuations depending on the monsoon season. Both children and farmers were recruited from each area. Despite methyl parathion's prohibited use in agriculture in 2004, we detected PNP in >90% of all samples analyzed. We applied a nonparametric correlation test (PNP vs. DMP and DMTP) to determine whether the PNP found in most of the samples tested resulted from exposures to methyl parathion. DMP (Spearman's rho = 0.601 [p = 0.001] for farmers and Spearman's rho = 0.263 [p <0.001] for children) and DMTP (Spearman's rho = 0.296 [p = 0.003] for farmers and Spearman's rho = 0.304 [p<0.001] for children) were positively correlated with PNP, suggesting a common source for the three analytes, presumably methyl parathion or related environmental degradates. Although we found a modest correlation between the metabolites, our findings suggest that despite the prohibition, at least a portion (approximately 25% to 60%) of the PNP detected among farmers and children in Thailand may be attributed to exposure from continued methyl parathion use.

Original languageEnglish (US)
Pages (from-to)623-629
Number of pages7
JournalArchives of Environmental Contamination and Toxicology
Volume57
Issue number3
DOIs
StatePublished - Apr 14 2009

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Methyl Parathion
Metabolites
Population
Thailand
Agriculture
Urine
Monitoring
Environmental Monitoring
Climate
Farmers
dimethyl phosphate

ASJC Scopus subject areas

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Panuwet, P., Prapamontol, T., Chantara, S., Thavornyuthikarn, P., Bravo, R., Restrepo, P., ... Barr, D. B. (2009). Urinary paranitrophenol, a metabolite of methyl parathion, in thai farmer and child populations. Archives of Environmental Contamination and Toxicology, 57(3), 623-629. https://doi.org/10.1007/s00244-009-9315-x

Urinary paranitrophenol, a metabolite of methyl parathion, in thai farmer and child populations. / Panuwet, Parinya; Prapamontol, Tippawan; Chantara, Somporn; Thavornyuthikarn, Prasak; Bravo, Roberto; Restrepo, Paula; Walker, Robert D.; Williams, Bryan L; Needham, Larry L.; Barr, Dana B.

In: Archives of Environmental Contamination and Toxicology, Vol. 57, No. 3, 14.04.2009, p. 623-629.

Research output: Contribution to journalArticle

Panuwet, P, Prapamontol, T, Chantara, S, Thavornyuthikarn, P, Bravo, R, Restrepo, P, Walker, RD, Williams, BL, Needham, LL & Barr, DB 2009, 'Urinary paranitrophenol, a metabolite of methyl parathion, in thai farmer and child populations', Archives of Environmental Contamination and Toxicology, vol. 57, no. 3, pp. 623-629. https://doi.org/10.1007/s00244-009-9315-x
Panuwet, Parinya ; Prapamontol, Tippawan ; Chantara, Somporn ; Thavornyuthikarn, Prasak ; Bravo, Roberto ; Restrepo, Paula ; Walker, Robert D. ; Williams, Bryan L ; Needham, Larry L. ; Barr, Dana B. / Urinary paranitrophenol, a metabolite of methyl parathion, in thai farmer and child populations. In: Archives of Environmental Contamination and Toxicology. 2009 ; Vol. 57, No. 3. pp. 623-629.
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abstract = "Human exposure to methyl parathion can be assessed by measuring the concentration of its metabolite paranitrophenol (PNP) in urine. Our biologic monitoring study in Chiang Mai, Thailand, measured PNP and dialkylphosphate metabolites (i.e., dimethylphosphate [DMP] and dimethylthiophosphate [DMTP]) of methyl parathion in urine samples collected from 136 farmers (age 20 to 65 years) and 306 school children (age 10 to 15 years) in 2006. Participants came from two topographically different areas: one was colder and mountainous, whereas the other was alluvial with climate fluctuations depending on the monsoon season. Both children and farmers were recruited from each area. Despite methyl parathion's prohibited use in agriculture in 2004, we detected PNP in >90{\%} of all samples analyzed. We applied a nonparametric correlation test (PNP vs. DMP and DMTP) to determine whether the PNP found in most of the samples tested resulted from exposures to methyl parathion. DMP (Spearman's rho = 0.601 [p = 0.001] for farmers and Spearman's rho = 0.263 [p <0.001] for children) and DMTP (Spearman's rho = 0.296 [p = 0.003] for farmers and Spearman's rho = 0.304 [p<0.001] for children) were positively correlated with PNP, suggesting a common source for the three analytes, presumably methyl parathion or related environmental degradates. Although we found a modest correlation between the metabolites, our findings suggest that despite the prohibition, at least a portion (approximately 25{\%} to 60{\%}) of the PNP detected among farmers and children in Thailand may be attributed to exposure from continued methyl parathion use.",
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AU - Panuwet, Parinya

AU - Prapamontol, Tippawan

AU - Chantara, Somporn

AU - Thavornyuthikarn, Prasak

AU - Bravo, Roberto

AU - Restrepo, Paula

AU - Walker, Robert D.

AU - Williams, Bryan L

AU - Needham, Larry L.

AU - Barr, Dana B.

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