Urinary prostasin: A possible biomarker for renal pressure natriuresis in black adolescents

Haidong Zhu, Julie Chao, Dehuang Guo, Ke Li, Ying Huang, Kimberly Hawkins, Nikki Wright, Inger Stallmann-Jorgensen, Weili Yan, Gregory A Harshfield, Yanbin Dong

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Prostasin is a membrane-bound/secretive serine protease interacting with aldosterone and the epithelial sodium channel in the kidney. We and others have previously proposed the concept of stress-induced pressure natriuresis (SIPN) where increased urinary sodium excretion (UNaV) is coupled with elevated blood pressure (BP) in response to behavioral stress in normotensive adolescents. This study thus aimed to test the relationship between prostasin and pressure natriuresis using the SIPN model. A cohort of 102 normotensive black adolescents (mean age: 17.0 ± 1.2 y; 56% females) were placed on a controlled sodium (4000 ± 200 mg/d) and potassium (2600 ± 200 mg/d) diet for three days before testing. The SIPN protocol consisted of a 1-h baseline period, a 1-h stress period (competitive video game), and a 1-h recovery period. During the stress period, BP elevation was coupled with an increase in UNaV. Urinary prostasin concentration had more than a 2-fold reduction from baseline (38.4 ± 32.7 ng/mL) to stress (17.2 ± 16.0 ng/mL), and further declined during recovery (12.1 ± 16.2 ng/mL) (p < 0.001). Urinary prostasin was inversely correlated with UNaV during stress (r = -0.43, p = 0.0001), even after being normalized by urinary creatinine. Our data suggest that urinary prostasin could be a novel biomarker and/or mechanism for renal pressure natriuresis in normotensive black adolescents.

Original languageEnglish (US)
Pages (from-to)443-446
Number of pages4
JournalPediatric research
Volume65
Issue number4
DOIs
StatePublished - Apr 2009

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Zhu, H., Chao, J., Guo, D., Li, K., Huang, Y., Hawkins, K., Wright, N., Stallmann-Jorgensen, I., Yan, W., Harshfield, G. A., & Dong, Y. (2009). Urinary prostasin: A possible biomarker for renal pressure natriuresis in black adolescents. Pediatric research, 65(4), 443-446. https://doi.org/10.1203/PDR.0b013e3181994b85