TY - JOUR
T1 - Urinary tract infection, inflammation, and cognition in phase 1 of the clinical antipsychotic trials of intervention effectiveness study
AU - Thomas, Joshua
AU - McEvoy, Joseph P.
AU - Miller, Brian J.
PY - 2019/11
Y1 - 2019/11
N2 - background: Schizophrenia is associated with an increased prevalence of infections throughout the life span. Previous studies have found an association between urinary tract infection (UTI) and acute psychosis. We investigated the prevalence and correlates of UTI in a large cohort of patients with schizophrenia. methods: We estimated the prevalence of UTI at the baseline visit of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial. We then investigated associations between UTI and inflammatory markers, psychopathology, and cognition, controlling for potential confounding factors. results: The prevalence of probable UTI at baseline in the CATIE trial was 1.2% (n = 13 of 1,061 participants). Compared with participants with a normal urinalysis (n = 387), after controlling for potential confounders, UTI was a significant predictor of greater impairments (approximately 1 standard deviation difference) in the cognition composite score (beta =-0.153, P = .002), and poorer working memory (beta =-0.190, P < .001). There were no differences in psychopathology scores between participants with probable UTI and those with a normal urinalysis. conclusions: Urinary tract infections in patients with schizophrenia may have an impact on cognition. Findings provide additional evidence regarding infectious disease comorbidity, which maybe clinically relevant in the treatment of patients with schizophrenia.
AB - background: Schizophrenia is associated with an increased prevalence of infections throughout the life span. Previous studies have found an association between urinary tract infection (UTI) and acute psychosis. We investigated the prevalence and correlates of UTI in a large cohort of patients with schizophrenia. methods: We estimated the prevalence of UTI at the baseline visit of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial. We then investigated associations between UTI and inflammatory markers, psychopathology, and cognition, controlling for potential confounding factors. results: The prevalence of probable UTI at baseline in the CATIE trial was 1.2% (n = 13 of 1,061 participants). Compared with participants with a normal urinalysis (n = 387), after controlling for potential confounders, UTI was a significant predictor of greater impairments (approximately 1 standard deviation difference) in the cognition composite score (beta =-0.153, P = .002), and poorer working memory (beta =-0.190, P < .001). There were no differences in psychopathology scores between participants with probable UTI and those with a normal urinalysis. conclusions: Urinary tract infections in patients with schizophrenia may have an impact on cognition. Findings provide additional evidence regarding infectious disease comorbidity, which maybe clinically relevant in the treatment of patients with schizophrenia.
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M3 - Article
C2 - 31675385
AN - SCOPUS:85074443437
SN - 1040-1237
VL - 31
SP - 242
EP - 248
JO - Annals of Clinical Psychiatry
JF - Annals of Clinical Psychiatry
IS - 4
ER -