Use of nonsteroidal antiinflammatory drugs and distal large bowel cancer in whites and African Americans

Sangmi Kim, Christopher Martin, Joseph Galanko, John T. Woosley, Jane C. Schroeder, Temitope O. Keku, Jessie A. Satia, Susan Halabi, Robert S. Sandler

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Despite the belief that the etiology of and risk factors for rectal cancer might differ from those for colon cancer, relatively few studies have examined rectal cancer in relation to use of nonsteroidal antiinflammatory drugs (NSAIDs). The authors evaluated the association between NSAIDs and distal large bowel cancer in African Americans and whites, using data from a population-based case-control study of 1,057 incident cases of adenocarcinoma of the sigmoid colon, rectosigmoid junction, and rectum and 1,019 controls from North Carolina (2001-2006). NSAID use was inversely associated with distal large bowel cancer in whites (odds ratio (OR) = 0.60, 95% confidence interval (CI): 0.46, 0.79). The inverse association was evident for all types of NSAIDs but was slightly stronger with prescription NSAIDs, particularly selective cyclooxygenase 2 inhibitors (OR = 0.38, 95% CI: 0.25, 0.56). Compared with whites, a relatively weak inverse association was found in African Americans (OR = 0.87, 95% CI: 0.55, 1.40), although odds ratio heterogeneity by race could not be confirmed (P = 0.21). In addition, the strength of the association with NSAIDs varied by tumor location, suggesting more potent effects for rectal and rectosigmoid cancers than for sigmoid cancer. The chemopreventive potential of NSAIDs might differ by population and by tumor characteristics.

Original languageEnglish (US)
Pages (from-to)1292-1300
Number of pages9
JournalAmerican journal of epidemiology
Volume168
Issue number11
DOIs
StatePublished - Dec 1 2008

Fingerprint

African Americans
Colonic Neoplasms
Anti-Inflammatory Agents
Pharmaceutical Preparations
Rectal Neoplasms
Odds Ratio
Sigmoid Neoplasms
Confidence Intervals
Cyclooxygenase 2 Inhibitors
Sigmoid Colon
Population Characteristics
Rectum
Prescriptions
Case-Control Studies
Neoplasms
Adenocarcinoma
Population

Keywords

  • Anti-inflammatory agents, non-steroidal
  • Colonic neoplasms
  • Colorectal neoplasms
  • Intestine, large
  • Population groups
  • Rectal neoplasms

ASJC Scopus subject areas

  • Epidemiology

Cite this

Kim, S., Martin, C., Galanko, J., Woosley, J. T., Schroeder, J. C., Keku, T. O., ... Sandler, R. S. (2008). Use of nonsteroidal antiinflammatory drugs and distal large bowel cancer in whites and African Americans. American journal of epidemiology, 168(11), 1292-1300. https://doi.org/10.1093/aje/kwn255

Use of nonsteroidal antiinflammatory drugs and distal large bowel cancer in whites and African Americans. / Kim, Sangmi; Martin, Christopher; Galanko, Joseph; Woosley, John T.; Schroeder, Jane C.; Keku, Temitope O.; Satia, Jessie A.; Halabi, Susan; Sandler, Robert S.

In: American journal of epidemiology, Vol. 168, No. 11, 01.12.2008, p. 1292-1300.

Research output: Contribution to journalArticle

Kim, S, Martin, C, Galanko, J, Woosley, JT, Schroeder, JC, Keku, TO, Satia, JA, Halabi, S & Sandler, RS 2008, 'Use of nonsteroidal antiinflammatory drugs and distal large bowel cancer in whites and African Americans', American journal of epidemiology, vol. 168, no. 11, pp. 1292-1300. https://doi.org/10.1093/aje/kwn255
Kim, Sangmi ; Martin, Christopher ; Galanko, Joseph ; Woosley, John T. ; Schroeder, Jane C. ; Keku, Temitope O. ; Satia, Jessie A. ; Halabi, Susan ; Sandler, Robert S. / Use of nonsteroidal antiinflammatory drugs and distal large bowel cancer in whites and African Americans. In: American journal of epidemiology. 2008 ; Vol. 168, No. 11. pp. 1292-1300.
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