Use of radiopharmaceuticals in diagnostic nuclear medicine in the United States: 1960-2010

Vladimir Drozdovitch, Aaron B. Brill, Ronald J. Callahan, Jeffrey A. Clanton, Allegra Depietro, Stanley J. Goldsmith, Bennett S. Greenspan, Milton D. Gross, Marguerite T. Hays, Stephen C. Moore, James A. Ponto, Walton W. Shreeve, Dunstana R. Melo, Martha S. Linet, Steven L. Simon

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

To reconstruct reliable nuclear medicine-related occupational radiation doses or doses received as patients from radiopharmaceuticals over the last five decades, the authors assessed which radiopharmaceuticals were used in different time periods, their relative frequency of use, and typical values of the administered activity. This paper presents data on the changing patterns of clinical use of radiopharmaceuticals and documents the range of activity administered to adult patients undergoing diagnostic nuclear medicine procedures in the U.S. between 1960 and 2010. Data are presented for 15 diagnostic imaging procedures that include thyroid scan and thyroid uptake; brain scan; brain blood flow; lung perfusion and ventilation; bone, liver, hepatobiliary, bonemarrow, pancreas, and kidney scans; cardiac imaging procedures; tumor localization studies; localization of gastrointestinal bleeding; and non-imaging studies of blood volume and iron metabolism. Data on the relative use of radiopharmaceuticals were collected using key informant interviews and comprehensive literature reviews of typical administered activities of these diagnostic nuclear medicine studies. Responses of key informants on relative use of radiopharmaceuticals are in agreement with published literature. Results of this study will be used for retrospective reconstruction of occupational and personal medical radiation doses from diagnostic radiopharmaceuticals to members of the U.S. radiologic technologists' cohort and in reconstructing radiation doses from occupational or patient radiation exposures to other U.S. workers or patient populations.

Original languageEnglish (US)
Pages (from-to)520-537
Number of pages18
JournalHealth physics
Volume108
Issue number5
DOIs
StatePublished - May 10 2015

Fingerprint

Radiopharmaceuticals
Nuclear Medicine
Radiation
Thyroid Gland
Brain
Diagnostic Imaging
Blood Volume
Ventilation
Pancreas
Iron
Perfusion
Interviews
Hemorrhage
Kidney
Bone and Bones
Lung
Liver
Population
Neoplasms

Keywords

  • diagnostic imaging
  • nuclear medicine
  • radiation, medical
  • radiopharmaceuticals

ASJC Scopus subject areas

  • Epidemiology
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis

Cite this

Drozdovitch, V., Brill, A. B., Callahan, R. J., Clanton, J. A., Depietro, A., Goldsmith, S. J., ... Simon, S. L. (2015). Use of radiopharmaceuticals in diagnostic nuclear medicine in the United States: 1960-2010. Health physics, 108(5), 520-537. https://doi.org/10.1097/HP.0000000000000261

Use of radiopharmaceuticals in diagnostic nuclear medicine in the United States : 1960-2010. / Drozdovitch, Vladimir; Brill, Aaron B.; Callahan, Ronald J.; Clanton, Jeffrey A.; Depietro, Allegra; Goldsmith, Stanley J.; Greenspan, Bennett S.; Gross, Milton D.; Hays, Marguerite T.; Moore, Stephen C.; Ponto, James A.; Shreeve, Walton W.; Melo, Dunstana R.; Linet, Martha S.; Simon, Steven L.

In: Health physics, Vol. 108, No. 5, 10.05.2015, p. 520-537.

Research output: Contribution to journalArticle

Drozdovitch, V, Brill, AB, Callahan, RJ, Clanton, JA, Depietro, A, Goldsmith, SJ, Greenspan, BS, Gross, MD, Hays, MT, Moore, SC, Ponto, JA, Shreeve, WW, Melo, DR, Linet, MS & Simon, SL 2015, 'Use of radiopharmaceuticals in diagnostic nuclear medicine in the United States: 1960-2010', Health physics, vol. 108, no. 5, pp. 520-537. https://doi.org/10.1097/HP.0000000000000261
Drozdovitch V, Brill AB, Callahan RJ, Clanton JA, Depietro A, Goldsmith SJ et al. Use of radiopharmaceuticals in diagnostic nuclear medicine in the United States: 1960-2010. Health physics. 2015 May 10;108(5):520-537. https://doi.org/10.1097/HP.0000000000000261
Drozdovitch, Vladimir ; Brill, Aaron B. ; Callahan, Ronald J. ; Clanton, Jeffrey A. ; Depietro, Allegra ; Goldsmith, Stanley J. ; Greenspan, Bennett S. ; Gross, Milton D. ; Hays, Marguerite T. ; Moore, Stephen C. ; Ponto, James A. ; Shreeve, Walton W. ; Melo, Dunstana R. ; Linet, Martha S. ; Simon, Steven L. / Use of radiopharmaceuticals in diagnostic nuclear medicine in the United States : 1960-2010. In: Health physics. 2015 ; Vol. 108, No. 5. pp. 520-537.
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