Use of the PROACT™ System for reduction of postsurgical peritoneal adhesions

Michael Peter Diamond, Kathy Stecco, Amelia J. Paulson

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To assess the efficacy and safety of a new surgical device designed to prevent adhesions. Design: Prospective, controlled two-phase porcine study. Setting: Good Laboratory Practice-certified animal facility. Animal(s): Phase I: 10 pigs underwent peritoneal treatment with the PROACT™ System (NTERO Surgical, Inc., Palo Alto, California) at the time of the laparotomy incision, and four had the incision made without treatment. Phase II: 22 animals were randomized to treatment or control groups. Intervention(s): Animals in both groups underwent laparotomy incision and small bowel resection. The treatment group received treatment to the peritoneum before the peritoneal incision was made. Necropsy and adhesion evaluation were conducted by a blinded reviewer 7-13 days after the initial surgery. Main Outcome Measure(s): Presence or absence of adhesions. Result(s): Phase I: no treated animal developed adhesions to the incision site; three of four control animals developed adhesions to the incision site. Phase II: 4 of 10 control animals and no treated animals developed midline abdominal wall adhesions. Distal adhesions tended to also be reduced in treated animals. No side effects or increased risks were noted. Conclusion(s): The PROACT™ System appears to be safe and efficacious in reducing adhesions to the laparotomy incision line in the porcine model.

Original languageEnglish (US)
Pages (from-to)198-202
Number of pages5
JournalFertility and sterility
Volume79
Issue number1
DOIs
StatePublished - Jan 1 2003

Fingerprint

Laparotomy
Swine
Peritoneum
Abdominal Wall
Outcome Assessment (Health Care)
Safety
Equipment and Supplies
Control Groups

Keywords

  • Adhesions
  • Incision line
  • PROACT™ System
  • Postoperative adhesions

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Use of the PROACT™ System for reduction of postsurgical peritoneal adhesions. / Diamond, Michael Peter; Stecco, Kathy; Paulson, Amelia J.

In: Fertility and sterility, Vol. 79, No. 1, 01.01.2003, p. 198-202.

Research output: Contribution to journalArticle

Diamond, Michael Peter ; Stecco, Kathy ; Paulson, Amelia J. / Use of the PROACT™ System for reduction of postsurgical peritoneal adhesions. In: Fertility and sterility. 2003 ; Vol. 79, No. 1. pp. 198-202.
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