Uterine cavity findings and hysteroscopic interventions in patients undergoing in vitro fertilization-embryo transfer who repeatedly cannot conceive

Flávio G. Oliveira, Vicente G. Abdelmassih, Michael Peter Diamond, Dimitri Dozortsev, Zsolt P. Nagy, Roger Abdelmassih

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Objective: To assess hysteroscopic findings in patients undergoing IVF-ET who repeatedly failed to conceive despite transfer of good-quality embryos. Design: Prospective, observational study. Setting: Clinical research unit for reproductive medicine in a private clinic. Patient(s): Fifty-five patients with a normal uterine cavity on hysterosalpingography before the initial IVF-ET cycle and two previous failed IVF-ET attempts despite transfer of a minimum of two good-quality embryos on each occasion. Intervention(s): Standard transvaginal ultrasonography and diagnostic and therapeutic hysteroscopy. Main Outcome Measure(s): Endometrial findings on transvaginal ultrasonography and hysteroscopy and outcome of the cycles after surgical hysteroscopy and antibiotic therapy. Result(s): Twenty-five (45%) patients had abnormal endometrial findings and underwent treatment to correct the lesions. All patients underwent a third IVF-ET cycle. Pregnancy (50% vs. 20%) and implantation (19% vs. 5.5%) rates were significantly higher in patients who were treated for uterine abnormalities than in patients who had normal uterine cavities on hysteroscopy. Conclusion(s): The incidence of pathologic findings on hysteroscopy is high in patients with repeated failures of IVF-ET. Evaluation of endometrial integrity by hysteroscopy is highly valuable and should be applied to all such cases.

Original languageEnglish (US)
Pages (from-to)1371-1375
Number of pages5
JournalFertility and Sterility
Volume80
Issue number6
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

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Embryo Transfer
Fertilization in Vitro
Hysteroscopy
Ultrasonography
Embryonic Structures
Hysterosalpingography
Reproductive Medicine
Observational Studies
Therapeutics
Outcome Assessment (Health Care)
Prospective Studies
Anti-Bacterial Agents
Pregnancy
Incidence
Research

Keywords

  • Embryo quality
  • Hysteroscopy
  • IVF-ET
  • Implantation failure

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Uterine cavity findings and hysteroscopic interventions in patients undergoing in vitro fertilization-embryo transfer who repeatedly cannot conceive. / Oliveira, Flávio G.; Abdelmassih, Vicente G.; Diamond, Michael Peter; Dozortsev, Dimitri; Nagy, Zsolt P.; Abdelmassih, Roger.

In: Fertility and Sterility, Vol. 80, No. 6, 01.01.2003, p. 1371-1375.

Research output: Contribution to journalArticle

Oliveira, Flávio G. ; Abdelmassih, Vicente G. ; Diamond, Michael Peter ; Dozortsev, Dimitri ; Nagy, Zsolt P. ; Abdelmassih, Roger. / Uterine cavity findings and hysteroscopic interventions in patients undergoing in vitro fertilization-embryo transfer who repeatedly cannot conceive. In: Fertility and Sterility. 2003 ; Vol. 80, No. 6. pp. 1371-1375.
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