Vaginitis Due to Saccharomyces cerevisiae: Epidemiology, Clinical Aspects, and Therapy

J. D. Sobel, Jose Antonio Vazquez, M. Lynch, C. Meriwether, M. J. Zervos

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Vaginitis due to Saccharomyces species is extremely rare. Nine patients with 20 vaginal isolates of Saccharomyces cerevisiae who presented with either asymptomatic vaginal colonization or symptomatic vaginitis indistinguishable from that caused by Candida albicans are described. All patients had a history of chronic or recurrent vaginitis, and all but two had systemic or local predisposing factors. In vitro tests of antimycotic sensitivity revealed reduced susceptibility of S. cerevisiae to the majority of available azole agents, with outright resistance to fluconazole. In accordance with these findings, the clinical response to conventional topical and oral antimycotic drugs was frequently suboptimal and incomplete. Electrophoretic karyotyping of strains revealed several distinct types of S. cerevisiae; this information permitted both longitudinal follow-up and differentiation of relapse from reinfection. In three patients with recurrent vaginitis, a unique epidemiological relationship was documented between S. cerevisiae and Torulopsis glabrata, another unusual and resistant vaginal pathogen. Isolation of S. cerevisiae from the vagina of symptomatic patients should not be ignored; treatment of vaginal infection with this yeast requires selected, often prolonged therapy.

Original languageEnglish (US)
Pages (from-to)93-99
Number of pages7
JournalClinical Infectious Diseases
Volume16
Issue number1
DOIs
StatePublished - Jan 1 1993

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Vaginitis
Saccharomyces cerevisiae
Epidemiology
Candida glabrata
Therapeutics
Karyotyping
Azoles
Saccharomyces
Fluconazole
Vagina
Candida albicans
Causality
Yeasts
Recurrence
Infection
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Vaginitis Due to Saccharomyces cerevisiae : Epidemiology, Clinical Aspects, and Therapy. / Sobel, J. D.; Vazquez, Jose Antonio; Lynch, M.; Meriwether, C.; Zervos, M. J.

In: Clinical Infectious Diseases, Vol. 16, No. 1, 01.01.1993, p. 93-99.

Research output: Contribution to journalArticle

Sobel, J. D. ; Vazquez, Jose Antonio ; Lynch, M. ; Meriwether, C. ; Zervos, M. J. / Vaginitis Due to Saccharomyces cerevisiae : Epidemiology, Clinical Aspects, and Therapy. In: Clinical Infectious Diseases. 1993 ; Vol. 16, No. 1. pp. 93-99.
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