Validating quantitative obesity measurements in colorectal cancer patients

Courtney J. Balentine, Christy Marshall, Celia Robinson, Jonathan Wilks, Daniel Anaya, Daniel Albo, David H. Berger

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Over 70,000,000 American adults are overweight, and obesity accounts for $147 billion annually in medical expenses. Since measuring obesity by body mass index (BMI) fails to account for fat distribution and quantity, recent work has explored quantitative measures of visceral fat area (VFA) and subcutaneous fat area (SFA) obtained from CT imaging. However, use of CT to quantify adipose tissue has not been evaluated in colorectal cancer (CRC) patients and the optimal anatomic location for measuring VFA and SFA has yet to be determined. We measured VFA and SFA at three different anatomic locations to determine which location was optimal in CRC patients. Methods: A database of patients undergoing CRC surgery from 2002 to 2009 was reviewed to identify patients with preoperative CT imaging. Quantitative measurements of both VFA and SFA were calculated at the level of L4-L5, L2-L3, and mid-waist. Results: A total of 244 colorectal cancer patients had preoperative imaging available and 99% were men. VFA and SFA quantified by CT at the levels of L2-L3, L4-L5, and mid-waist were all significant independent predictors for medical complications of obesity including diabetes (HR 1.04 -1.06) and hypertension (HR 1.04-1.09) on multivariate analysis. The location used for imaging did not affect predictive power. Additionally, waist circumference was also a significant independent predictor of diabetes (HR 1.56) and hypertension (HR 1.70). Conclusions: Quantitative measures of obesity from CT imaging in CRC patients correlated significantly with medical conditions known to be associated with obesity. This indicates that direct measurement of adiposity is valid in colorectal cancer patients.

Original languageEnglish (US)
Pages (from-to)18-22
Number of pages5
JournalJournal of Surgical Research
Volume164
Issue number1
DOIs
StatePublished - Nov 1 2010
Externally publishedYes

Fingerprint

Colorectal Neoplasms
Intra-Abdominal Fat
Subcutaneous Fat
Obesity
Hypertension
Colorectal Surgery
Adiposity
Waist Circumference
Adipose Tissue
Body Mass Index
Multivariate Analysis
Fats
Databases

Keywords

  • colorectal cancer
  • subcutaneous obesity
  • visceral obesity

ASJC Scopus subject areas

  • Surgery

Cite this

Balentine, C. J., Marshall, C., Robinson, C., Wilks, J., Anaya, D., Albo, D., & Berger, D. H. (2010). Validating quantitative obesity measurements in colorectal cancer patients. Journal of Surgical Research, 164(1), 18-22. https://doi.org/10.1016/j.jss.2010.05.048

Validating quantitative obesity measurements in colorectal cancer patients. / Balentine, Courtney J.; Marshall, Christy; Robinson, Celia; Wilks, Jonathan; Anaya, Daniel; Albo, Daniel; Berger, David H.

In: Journal of Surgical Research, Vol. 164, No. 1, 01.11.2010, p. 18-22.

Research output: Contribution to journalArticle

Balentine, CJ, Marshall, C, Robinson, C, Wilks, J, Anaya, D, Albo, D & Berger, DH 2010, 'Validating quantitative obesity measurements in colorectal cancer patients', Journal of Surgical Research, vol. 164, no. 1, pp. 18-22. https://doi.org/10.1016/j.jss.2010.05.048
Balentine, Courtney J. ; Marshall, Christy ; Robinson, Celia ; Wilks, Jonathan ; Anaya, Daniel ; Albo, Daniel ; Berger, David H. / Validating quantitative obesity measurements in colorectal cancer patients. In: Journal of Surgical Research. 2010 ; Vol. 164, No. 1. pp. 18-22.
@article{513e4d446f0d43048c477270240eef84,
title = "Validating quantitative obesity measurements in colorectal cancer patients",
abstract = "Background: Over 70,000,000 American adults are overweight, and obesity accounts for $147 billion annually in medical expenses. Since measuring obesity by body mass index (BMI) fails to account for fat distribution and quantity, recent work has explored quantitative measures of visceral fat area (VFA) and subcutaneous fat area (SFA) obtained from CT imaging. However, use of CT to quantify adipose tissue has not been evaluated in colorectal cancer (CRC) patients and the optimal anatomic location for measuring VFA and SFA has yet to be determined. We measured VFA and SFA at three different anatomic locations to determine which location was optimal in CRC patients. Methods: A database of patients undergoing CRC surgery from 2002 to 2009 was reviewed to identify patients with preoperative CT imaging. Quantitative measurements of both VFA and SFA were calculated at the level of L4-L5, L2-L3, and mid-waist. Results: A total of 244 colorectal cancer patients had preoperative imaging available and 99{\%} were men. VFA and SFA quantified by CT at the levels of L2-L3, L4-L5, and mid-waist were all significant independent predictors for medical complications of obesity including diabetes (HR 1.04 -1.06) and hypertension (HR 1.04-1.09) on multivariate analysis. The location used for imaging did not affect predictive power. Additionally, waist circumference was also a significant independent predictor of diabetes (HR 1.56) and hypertension (HR 1.70). Conclusions: Quantitative measures of obesity from CT imaging in CRC patients correlated significantly with medical conditions known to be associated with obesity. This indicates that direct measurement of adiposity is valid in colorectal cancer patients.",
keywords = "colorectal cancer, subcutaneous obesity, visceral obesity",
author = "Balentine, {Courtney J.} and Christy Marshall and Celia Robinson and Jonathan Wilks and Daniel Anaya and Daniel Albo and Berger, {David H.}",
year = "2010",
month = "11",
day = "1",
doi = "10.1016/j.jss.2010.05.048",
language = "English (US)",
volume = "164",
pages = "18--22",
journal = "Journal of Surgical Research",
issn = "0022-4804",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Validating quantitative obesity measurements in colorectal cancer patients

AU - Balentine, Courtney J.

AU - Marshall, Christy

AU - Robinson, Celia

AU - Wilks, Jonathan

AU - Anaya, Daniel

AU - Albo, Daniel

AU - Berger, David H.

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Background: Over 70,000,000 American adults are overweight, and obesity accounts for $147 billion annually in medical expenses. Since measuring obesity by body mass index (BMI) fails to account for fat distribution and quantity, recent work has explored quantitative measures of visceral fat area (VFA) and subcutaneous fat area (SFA) obtained from CT imaging. However, use of CT to quantify adipose tissue has not been evaluated in colorectal cancer (CRC) patients and the optimal anatomic location for measuring VFA and SFA has yet to be determined. We measured VFA and SFA at three different anatomic locations to determine which location was optimal in CRC patients. Methods: A database of patients undergoing CRC surgery from 2002 to 2009 was reviewed to identify patients with preoperative CT imaging. Quantitative measurements of both VFA and SFA were calculated at the level of L4-L5, L2-L3, and mid-waist. Results: A total of 244 colorectal cancer patients had preoperative imaging available and 99% were men. VFA and SFA quantified by CT at the levels of L2-L3, L4-L5, and mid-waist were all significant independent predictors for medical complications of obesity including diabetes (HR 1.04 -1.06) and hypertension (HR 1.04-1.09) on multivariate analysis. The location used for imaging did not affect predictive power. Additionally, waist circumference was also a significant independent predictor of diabetes (HR 1.56) and hypertension (HR 1.70). Conclusions: Quantitative measures of obesity from CT imaging in CRC patients correlated significantly with medical conditions known to be associated with obesity. This indicates that direct measurement of adiposity is valid in colorectal cancer patients.

AB - Background: Over 70,000,000 American adults are overweight, and obesity accounts for $147 billion annually in medical expenses. Since measuring obesity by body mass index (BMI) fails to account for fat distribution and quantity, recent work has explored quantitative measures of visceral fat area (VFA) and subcutaneous fat area (SFA) obtained from CT imaging. However, use of CT to quantify adipose tissue has not been evaluated in colorectal cancer (CRC) patients and the optimal anatomic location for measuring VFA and SFA has yet to be determined. We measured VFA and SFA at three different anatomic locations to determine which location was optimal in CRC patients. Methods: A database of patients undergoing CRC surgery from 2002 to 2009 was reviewed to identify patients with preoperative CT imaging. Quantitative measurements of both VFA and SFA were calculated at the level of L4-L5, L2-L3, and mid-waist. Results: A total of 244 colorectal cancer patients had preoperative imaging available and 99% were men. VFA and SFA quantified by CT at the levels of L2-L3, L4-L5, and mid-waist were all significant independent predictors for medical complications of obesity including diabetes (HR 1.04 -1.06) and hypertension (HR 1.04-1.09) on multivariate analysis. The location used for imaging did not affect predictive power. Additionally, waist circumference was also a significant independent predictor of diabetes (HR 1.56) and hypertension (HR 1.70). Conclusions: Quantitative measures of obesity from CT imaging in CRC patients correlated significantly with medical conditions known to be associated with obesity. This indicates that direct measurement of adiposity is valid in colorectal cancer patients.

KW - colorectal cancer

KW - subcutaneous obesity

KW - visceral obesity

UR - http://www.scopus.com/inward/record.url?scp=77958102932&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77958102932&partnerID=8YFLogxK

U2 - 10.1016/j.jss.2010.05.048

DO - 10.1016/j.jss.2010.05.048

M3 - Article

C2 - 20828744

AN - SCOPUS:77958102932

VL - 164

SP - 18

EP - 22

JO - Journal of Surgical Research

JF - Journal of Surgical Research

SN - 0022-4804

IS - 1

ER -