Validation and Potential Mechanisms of Red Cell Distribution Width as a Prognostic Marker in Heart Failure

Larry A. Allen, G. Michael Felker, Mandeep R. Mehra, Jun R. Chiong, Stephanie Hope Dunlap, Jalal K. Ghali, Daniel J. Lenihan, Ron M. Oren, Lynne E. Wagoner, Todd A. Schwartz, Kirkwood F. Adams

Research output: Contribution to journalArticle

238 Scopus citations

Abstract

Background: Adverse outcomes have recently been linked to elevated red cell distribution width (RDW) in heart failure. Our study sought to validate the prognostic value of RDW in heart failure and to explore the potential mechanisms underlying this association. Methods and Results: Data from the Study of Anemia in a Heart Failure Population (STAMINA-HFP) registry, a prospective, multicenter cohort of ambulatory patients with heart failure supported multivariable modeling to assess relationships between RDW and outcomes. The association between RDW and iron metabolism, inflammation, and neurohormonal activation was studied in a separate cohort of heart failure patients from the United Investigators to Evaluate Heart Failure (UNITE-HF) Biomarker registry. RDW was independently predictive of outcome (for each 1% increase in RDW, hazard ratio for mortality 1.06, 95% CI 1.01-1.12; hazard ratio for hospitalization or mortality 1.06; 95% CI 1.02-1.10) after adjustment for other covariates. Increasing RDW correlated with decreasing hemoglobin, increasing interleukin-6, and impaired iron mobilization. Conclusions: Our results confirm previous observations that RDW is a strong, independent predictor of adverse outcome in chronic heart failure and suggest elevated RDW may indicate inflammatory stress and impaired iron mobilization. These findings encourage further research into the relationship between heart failure and the hematologic system.

Original languageEnglish (US)
Pages (from-to)230-238
Number of pages9
JournalJournal of Cardiac Failure
Volume16
Issue number3
DOIs
StatePublished - Mar 1 2010
Externally publishedYes

Keywords

  • Anemia
  • biomarker
  • laboratory tests

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Allen, L. A., Felker, G. M., Mehra, M. R., Chiong, J. R., Dunlap, S. H., Ghali, J. K., Lenihan, D. J., Oren, R. M., Wagoner, L. E., Schwartz, T. A., & Adams, K. F. (2010). Validation and Potential Mechanisms of Red Cell Distribution Width as a Prognostic Marker in Heart Failure. Journal of Cardiac Failure, 16(3), 230-238. https://doi.org/10.1016/j.cardfail.2009.11.003