Validation of fingernail fluoride concentration as a predictor of risk for dental fluorosis

M. A.R. Buzalaf, C. S. Massaro, M. H.C. Rodrigues, R. Fukushima, J. P. Pessan, Gary M. Whitford, F. C. Sampaio

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The aim of this study was to validate the use of fingernail fluoride concentrations at ages 2-7 years as predictors of the risk for developing dental fluorosis in the permanent dentition. Fifty-six children of both genders (10-15 years of age) had their incisors and premolars examined for dental fluorosis using the Thylstrup-Fejerskov index. Fingernail fluoride concentrations were obtained from previous studies when children were 2-7 years of age. Data were analyzed by unpaired t test, ANOVA, and Fisher's exact test when the fingernail fluoride concentrations were dichotomized (≤2 or >2 μg/g). Children with dental fluorosis had significantly higher fingernail fluoride concentrations than those without the condition, and the concentrations tended to increase with the severity of fluorosis (r2 = 0.47, p < 0.0001). Using a fingernail fluoride concentration of 2 μg/g at ages 2-7 years as a threshold, this biomarker had high sensitivity (0.84) and moderate specificity (0.53) as a predictor for dental fluorosis. The high positive predictive value indicates that fingernail fluoride concentrations should be useful in public health research, since it has the potential to identify around 80% of children at risk of developing dental fluorosis.

Original languageEnglish (US)
Pages (from-to)394-400
Number of pages7
JournalCaries Research
Volume46
Issue number4
DOIs
StatePublished - Jul 1 2012

Fingerprint

Dental Fluorosis
Nails
Fluorides
Permanent Dentition
Bicuspid
Incisor
Analysis of Variance
Public Health
Biomarkers
Research

Keywords

  • Biomarker
  • Dental fluorosis
  • Fingernail
  • Fluoride

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Buzalaf, M. A. R., Massaro, C. S., Rodrigues, M. H. C., Fukushima, R., Pessan, J. P., Whitford, G. M., & Sampaio, F. C. (2012). Validation of fingernail fluoride concentration as a predictor of risk for dental fluorosis. Caries Research, 46(4), 394-400. https://doi.org/10.1159/000339088

Validation of fingernail fluoride concentration as a predictor of risk for dental fluorosis. / Buzalaf, M. A.R.; Massaro, C. S.; Rodrigues, M. H.C.; Fukushima, R.; Pessan, J. P.; Whitford, Gary M.; Sampaio, F. C.

In: Caries Research, Vol. 46, No. 4, 01.07.2012, p. 394-400.

Research output: Contribution to journalArticle

Buzalaf, MAR, Massaro, CS, Rodrigues, MHC, Fukushima, R, Pessan, JP, Whitford, GM & Sampaio, FC 2012, 'Validation of fingernail fluoride concentration as a predictor of risk for dental fluorosis', Caries Research, vol. 46, no. 4, pp. 394-400. https://doi.org/10.1159/000339088
Buzalaf, M. A.R. ; Massaro, C. S. ; Rodrigues, M. H.C. ; Fukushima, R. ; Pessan, J. P. ; Whitford, Gary M. ; Sampaio, F. C. / Validation of fingernail fluoride concentration as a predictor of risk for dental fluorosis. In: Caries Research. 2012 ; Vol. 46, No. 4. pp. 394-400.
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