Validation of simultaneous volumetric and spectrophotometric methods for the determination of captopril in pharmaceutical formulations

Nafisur Rahman, Manisha Singh, MD Nasrul Hoda

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Simple, sensitive and economical simultaneous volumetric and spectrophotometric methods for the determination of captopril have been developed. The methods were based on the reaction of captopril with potassium iodate in HCl medium. Amaranth was used as indicator to detect the end-point of the titration in aqueous layer. The iodine formed during the titration was extracted into CCl4 and subsequently determined spectrophotometrically at 510 nm. The Beer's law was obeyed in the concentration range of 120-520 μg ml-1. Rigorous statistical analyses were performed for the validation of the proposed methods. The proposed methods were successfully applied to the determination of captopril in dosage forms. Comparison of the means of the proposed procedures with those of reference methods using point and interval hypothesis tests showed no statistically significant difference.

Original languageEnglish (US)
Pages (from-to)569-574
Number of pages6
JournalFarmaco
Volume60
Issue number6-7
DOIs
StatePublished - Jun 1 2005

Keywords

  • Captopril
  • Potassium iodate
  • Spectrophotometry-titrimetry

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery

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