Abstract
Objective: To examine the ability to use parameters obtainable from an oral glucose tolerance test to predict insulin action as determined under hyperinsulinemic, hyperglycemic conditions. Design: Prospective clinical investigation. Setting: University medical center clinical research unit. Patient(s): Healthy male volunteers. Intervention(s): Oral glucose tolerance test and hyperglycemic (+125 mg/dL) clamp studies. Main Outcome Measure(s): Glucose and insulin (I) levels, rate of glucose uptake (M) under hyperglycemic conditions, and M/I ratios. Result(s): Among individuals with normal glucose tolerance, as assessed by an oral glucose tolerance test, the fasting insulin level is the glucose tolerance test parameter that correlates best with insulin action during a hyperglycemic clamp. Conclusion(s): Measurement of fasting serum insulin levels in conjunction with an oral glucose tolerance test improves the ability to assess insulin action. Such combinations may improve the ability to diagnose insulin-resistant states.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1022-1025 |
| Number of pages | 4 |
| Journal | Fertility and sterility |
| Volume | 80 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 1 2003 |
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Keywords
- Glucose
- Glucose tolerance
- Hyperglycemic clamp
- Insulin
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology
Cite this
Values of fasting glucose levels, glucose tolerance tests, and glucose-insulin ratios as predictors of glucose tolerance. / Diamond, Michael P.; Chauhan, Subodhsingh; Kruger, Michael; Subramanian, Marappa.
In: Fertility and sterility, Vol. 80, No. 4, 01.10.2003, p. 1022-1025.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Values of fasting glucose levels, glucose tolerance tests, and glucose-insulin ratios as predictors of glucose tolerance
AU - Diamond, Michael P.
AU - Chauhan, Subodhsingh
AU - Kruger, Michael
AU - Subramanian, Marappa
PY - 2003/10/1
Y1 - 2003/10/1
N2 - Objective: To examine the ability to use parameters obtainable from an oral glucose tolerance test to predict insulin action as determined under hyperinsulinemic, hyperglycemic conditions. Design: Prospective clinical investigation. Setting: University medical center clinical research unit. Patient(s): Healthy male volunteers. Intervention(s): Oral glucose tolerance test and hyperglycemic (+125 mg/dL) clamp studies. Main Outcome Measure(s): Glucose and insulin (I) levels, rate of glucose uptake (M) under hyperglycemic conditions, and M/I ratios. Result(s): Among individuals with normal glucose tolerance, as assessed by an oral glucose tolerance test, the fasting insulin level is the glucose tolerance test parameter that correlates best with insulin action during a hyperglycemic clamp. Conclusion(s): Measurement of fasting serum insulin levels in conjunction with an oral glucose tolerance test improves the ability to assess insulin action. Such combinations may improve the ability to diagnose insulin-resistant states.
AB - Objective: To examine the ability to use parameters obtainable from an oral glucose tolerance test to predict insulin action as determined under hyperinsulinemic, hyperglycemic conditions. Design: Prospective clinical investigation. Setting: University medical center clinical research unit. Patient(s): Healthy male volunteers. Intervention(s): Oral glucose tolerance test and hyperglycemic (+125 mg/dL) clamp studies. Main Outcome Measure(s): Glucose and insulin (I) levels, rate of glucose uptake (M) under hyperglycemic conditions, and M/I ratios. Result(s): Among individuals with normal glucose tolerance, as assessed by an oral glucose tolerance test, the fasting insulin level is the glucose tolerance test parameter that correlates best with insulin action during a hyperglycemic clamp. Conclusion(s): Measurement of fasting serum insulin levels in conjunction with an oral glucose tolerance test improves the ability to assess insulin action. Such combinations may improve the ability to diagnose insulin-resistant states.
KW - Glucose
KW - Glucose tolerance
KW - Hyperglycemic clamp
KW - Insulin
UR - http://www.scopus.com/inward/record.url?scp=0141923619&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0141923619&partnerID=8YFLogxK
U2 - 10.1016/S0015-0282(03)01016-1
DO - 10.1016/S0015-0282(03)01016-1
M3 - Article
C2 - 14556827
AN - SCOPUS:0141923619
VL - 80
SP - 1022
EP - 1025
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 4
ER -