TY - JOUR
T1 - Vascular α-adrenergic blocking properties of quinidine
AU - Caldwell, Robert W.
AU - Elam, Janet T.
AU - Mecca, Thomas E.
AU - Nash, Clinton B.
PY - 1983/10/28
Y1 - 1983/10/28
N2 - The specificity of the α-adrenergic vascular blockade by quinidine was tested in the inatct dog, in rabbit isolated aortic strips, and in rats under ganglionic blockade. Quinidine did not affect the pressor response of angiotensin II in dogs, the contractile response of histamine nor angiotensin II in aortic strips, nor the dose-pressor response curve of the α-agonist, B-HT 933 in the rat. However, the pressor effect of adrenaline and noradrenaline (NA) were significantly reduced in dogs, and the dose-response curves to NA in aortic strips and to the α-agonist, phenylphrine in rats was shifted to the right in a parallel manner by quinidine. In the rat, quinidine is at least 14 times more potent in antagonizing the vasopressor effect of an α1-vs. and α2-adrenoceptor agonist.
AB - The specificity of the α-adrenergic vascular blockade by quinidine was tested in the inatct dog, in rabbit isolated aortic strips, and in rats under ganglionic blockade. Quinidine did not affect the pressor response of angiotensin II in dogs, the contractile response of histamine nor angiotensin II in aortic strips, nor the dose-pressor response curve of the α-agonist, B-HT 933 in the rat. However, the pressor effect of adrenaline and noradrenaline (NA) were significantly reduced in dogs, and the dose-response curves to NA in aortic strips and to the α-agonist, phenylphrine in rats was shifted to the right in a parallel manner by quinidine. In the rat, quinidine is at least 14 times more potent in antagonizing the vasopressor effect of an α1-vs. and α2-adrenoceptor agonist.
KW - Ganglionic-blocked rat
KW - Quinidine
KW - α-vs. α-Adrenergic blockade
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U2 - 10.1016/0014-2999(83)90407-7
DO - 10.1016/0014-2999(83)90407-7
M3 - Article
C2 - 6140173
AN - SCOPUS:0021039834
SN - 0014-2999
VL - 94
SP - 185
EP - 192
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 3-4
ER -