Vascular endothelium summary statement V

Pulmonary hypertension and acute lung injury: Public health implications

W. Craig Hooper, George A. Mensah, S. G. Haworth, Stephen Matthew Black, Joe G.N. Garcia, David Langleben

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Although relatively rare, pulmonary hypertension can be devastating for those individuals who are affected and has significant societal implications. The 2003 WHO classification separates PAH (idiopathic, specific disease linked) from pulmonary hypertension related to lung disease, thromboembolic disease, and pulmonary venous hypertension. Another form of pulmonary hypertension, persistent pulmonary hypertension (PPHN), occurs in the newborn. In general, PPHN is thought to be responsible for approximately 10% of admissions to neonatal intensive care units and can be a complicating factor in 5 of 1000 live births. Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are complex disorders that pose a significant threat to critically ill patients. They are usually related to direct lung injury or indirect injury from sepsis, trauma, and other disorders. Although these pulmonary disorders reflect distinct pathophysiologic mechanisms, current evidence strongly suggests that a common denominator underlying many of the established molecular and cellualar elements is endothelial cell activation and dysfunction. This summary statement briefly summarizes the state of the science and suggests future avenues of public health research.

Original languageEnglish (US)
Pages (from-to)327-329
Number of pages3
JournalVascular Pharmacology
Volume46
Issue number5 SPEC. ISS.
DOIs
StatePublished - Jan 1 2007

Fingerprint

Acute Lung Injury
Vascular Endothelium
Pulmonary Hypertension
Public Health
Neonatal Intensive Care Units
Adult Respiratory Distress Syndrome
Wounds and Injuries
Live Birth
Lung Injury
Critical Illness
Lung Diseases
Sepsis
Endothelial Cells
Newborn Infant
Lung
Research

Keywords

  • Acute lung injury
  • Pulmonary hypertension
  • Vascular endothelium

ASJC Scopus subject areas

  • Physiology
  • Molecular Medicine
  • Pharmacology

Cite this

Hooper, W. C., Mensah, G. A., Haworth, S. G., Black, S. M., Garcia, J. G. N., & Langleben, D. (2007). Vascular endothelium summary statement V: Pulmonary hypertension and acute lung injury: Public health implications. Vascular Pharmacology, 46(5 SPEC. ISS.), 327-329. https://doi.org/10.1016/j.vph.2006.10.017

Vascular endothelium summary statement V : Pulmonary hypertension and acute lung injury: Public health implications. / Hooper, W. Craig; Mensah, George A.; Haworth, S. G.; Black, Stephen Matthew; Garcia, Joe G.N.; Langleben, David.

In: Vascular Pharmacology, Vol. 46, No. 5 SPEC. ISS., 01.01.2007, p. 327-329.

Research output: Contribution to journalArticle

Hooper, WC, Mensah, GA, Haworth, SG, Black, SM, Garcia, JGN & Langleben, D 2007, 'Vascular endothelium summary statement V: Pulmonary hypertension and acute lung injury: Public health implications', Vascular Pharmacology, vol. 46, no. 5 SPEC. ISS., pp. 327-329. https://doi.org/10.1016/j.vph.2006.10.017
Hooper, W. Craig ; Mensah, George A. ; Haworth, S. G. ; Black, Stephen Matthew ; Garcia, Joe G.N. ; Langleben, David. / Vascular endothelium summary statement V : Pulmonary hypertension and acute lung injury: Public health implications. In: Vascular Pharmacology. 2007 ; Vol. 46, No. 5 SPEC. ISS. pp. 327-329.
@article{9e4b9887c19f4c388b0afdd836007ebd,
title = "Vascular endothelium summary statement V: Pulmonary hypertension and acute lung injury: Public health implications",
abstract = "Although relatively rare, pulmonary hypertension can be devastating for those individuals who are affected and has significant societal implications. The 2003 WHO classification separates PAH (idiopathic, specific disease linked) from pulmonary hypertension related to lung disease, thromboembolic disease, and pulmonary venous hypertension. Another form of pulmonary hypertension, persistent pulmonary hypertension (PPHN), occurs in the newborn. In general, PPHN is thought to be responsible for approximately 10{\%} of admissions to neonatal intensive care units and can be a complicating factor in 5 of 1000 live births. Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are complex disorders that pose a significant threat to critically ill patients. They are usually related to direct lung injury or indirect injury from sepsis, trauma, and other disorders. Although these pulmonary disorders reflect distinct pathophysiologic mechanisms, current evidence strongly suggests that a common denominator underlying many of the established molecular and cellualar elements is endothelial cell activation and dysfunction. This summary statement briefly summarizes the state of the science and suggests future avenues of public health research.",
keywords = "Acute lung injury, Pulmonary hypertension, Vascular endothelium",
author = "Hooper, {W. Craig} and Mensah, {George A.} and Haworth, {S. G.} and Black, {Stephen Matthew} and Garcia, {Joe G.N.} and David Langleben",
year = "2007",
month = "1",
day = "1",
doi = "10.1016/j.vph.2006.10.017",
language = "English (US)",
volume = "46",
pages = "327--329",
journal = "Vascular Pharmacology",
issn = "1537-1891",
publisher = "Elsevier Inc.",
number = "5 SPEC. ISS.",

}

TY - JOUR

T1 - Vascular endothelium summary statement V

T2 - Pulmonary hypertension and acute lung injury: Public health implications

AU - Hooper, W. Craig

AU - Mensah, George A.

AU - Haworth, S. G.

AU - Black, Stephen Matthew

AU - Garcia, Joe G.N.

AU - Langleben, David

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Although relatively rare, pulmonary hypertension can be devastating for those individuals who are affected and has significant societal implications. The 2003 WHO classification separates PAH (idiopathic, specific disease linked) from pulmonary hypertension related to lung disease, thromboembolic disease, and pulmonary venous hypertension. Another form of pulmonary hypertension, persistent pulmonary hypertension (PPHN), occurs in the newborn. In general, PPHN is thought to be responsible for approximately 10% of admissions to neonatal intensive care units and can be a complicating factor in 5 of 1000 live births. Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are complex disorders that pose a significant threat to critically ill patients. They are usually related to direct lung injury or indirect injury from sepsis, trauma, and other disorders. Although these pulmonary disorders reflect distinct pathophysiologic mechanisms, current evidence strongly suggests that a common denominator underlying many of the established molecular and cellualar elements is endothelial cell activation and dysfunction. This summary statement briefly summarizes the state of the science and suggests future avenues of public health research.

AB - Although relatively rare, pulmonary hypertension can be devastating for those individuals who are affected and has significant societal implications. The 2003 WHO classification separates PAH (idiopathic, specific disease linked) from pulmonary hypertension related to lung disease, thromboembolic disease, and pulmonary venous hypertension. Another form of pulmonary hypertension, persistent pulmonary hypertension (PPHN), occurs in the newborn. In general, PPHN is thought to be responsible for approximately 10% of admissions to neonatal intensive care units and can be a complicating factor in 5 of 1000 live births. Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are complex disorders that pose a significant threat to critically ill patients. They are usually related to direct lung injury or indirect injury from sepsis, trauma, and other disorders. Although these pulmonary disorders reflect distinct pathophysiologic mechanisms, current evidence strongly suggests that a common denominator underlying many of the established molecular and cellualar elements is endothelial cell activation and dysfunction. This summary statement briefly summarizes the state of the science and suggests future avenues of public health research.

KW - Acute lung injury

KW - Pulmonary hypertension

KW - Vascular endothelium

UR - http://www.scopus.com/inward/record.url?scp=33847763259&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847763259&partnerID=8YFLogxK

U2 - 10.1016/j.vph.2006.10.017

DO - 10.1016/j.vph.2006.10.017

M3 - Article

VL - 46

SP - 327

EP - 329

JO - Vascular Pharmacology

JF - Vascular Pharmacology

SN - 1537-1891

IS - 5 SPEC. ISS.

ER -