Vascular reactivity in hypertension

Altered effect of ouabain

R Clinton Webb, D. F. Bohr

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Ouabain inhibits the relaxing effect of Ca2+ (but not of Mn2+) on contractile responses in tail artery strips isolated from spontaneously hypertensive and normotensive rats. The magnitude of ouabain inhibition was greater in vascular strips from hypertensive rats suggesting a significant difference in basic membrane function in hypertensive vascular smooth muscle.

Original languageEnglish (US)
Pages (from-to)220-222
Number of pages3
JournalExperientia
Volume36
Issue number2
DOIs
StatePublished - Feb 1 1980
Externally publishedYes

Fingerprint

Ouabain
Blood Vessels
Rats
Hypertension
Inbred SHR Rats
Vascular Smooth Muscle
Muscle
Tail
Arteries
Membranes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Vascular reactivity in hypertension : Altered effect of ouabain. / Webb, R Clinton; Bohr, D. F.

In: Experientia, Vol. 36, No. 2, 01.02.1980, p. 220-222.

Research output: Contribution to journalArticle

Webb, R Clinton ; Bohr, D. F. / Vascular reactivity in hypertension : Altered effect of ouabain. In: Experientia. 1980 ; Vol. 36, No. 2. pp. 220-222.
@article{d2349c1f2e654ec2805f88883b476f6c,
title = "Vascular reactivity in hypertension: Altered effect of ouabain",
abstract = "Ouabain inhibits the relaxing effect of Ca2+ (but not of Mn2+) on contractile responses in tail artery strips isolated from spontaneously hypertensive and normotensive rats. The magnitude of ouabain inhibition was greater in vascular strips from hypertensive rats suggesting a significant difference in basic membrane function in hypertensive vascular smooth muscle.",
author = "Webb, {R Clinton} and Bohr, {D. F.}",
year = "1980",
month = "2",
day = "1",
doi = "10.1007/BF01953743",
language = "English (US)",
volume = "36",
pages = "220--222",
journal = "Cellular and Molecular Life Sciences",
issn = "1420-682X",
publisher = "Birkhauser Verlag Basel",
number = "2",

}

TY - JOUR

T1 - Vascular reactivity in hypertension

T2 - Altered effect of ouabain

AU - Webb, R Clinton

AU - Bohr, D. F.

PY - 1980/2/1

Y1 - 1980/2/1

N2 - Ouabain inhibits the relaxing effect of Ca2+ (but not of Mn2+) on contractile responses in tail artery strips isolated from spontaneously hypertensive and normotensive rats. The magnitude of ouabain inhibition was greater in vascular strips from hypertensive rats suggesting a significant difference in basic membrane function in hypertensive vascular smooth muscle.

AB - Ouabain inhibits the relaxing effect of Ca2+ (but not of Mn2+) on contractile responses in tail artery strips isolated from spontaneously hypertensive and normotensive rats. The magnitude of ouabain inhibition was greater in vascular strips from hypertensive rats suggesting a significant difference in basic membrane function in hypertensive vascular smooth muscle.

UR - http://www.scopus.com/inward/record.url?scp=0018898936&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018898936&partnerID=8YFLogxK

U2 - 10.1007/BF01953743

DO - 10.1007/BF01953743

M3 - Article

VL - 36

SP - 220

EP - 222

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-682X

IS - 2

ER -