Vascular responsiveness to serotonin metabolites in mineralocorticoid hypertension

Loren P. Thompson, R Clinton Webb

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

This study characterizes vascular responsiveness to serotonin and its metabol ites and to several monoamines that are structurally related to serotonin in deoxycorticosterone acetate (DOCA)-salt hypertension. Mesenteric arteries from normotensive and hypertensive rats were excised and cut into helical strips for isometric force recording. Dose-response curves to serotonin in arteries from hypertensive rats were shifted significantly to the left compared with those in arteries from normotensive rats (ED25: DOCA-treated = 2.4 × 10-8 M; control = 17.1 × 10-8 M). Contractile responses to 5-hydroxyindole acetic acid and 5-hydroxytryptophol were greater in mesenteric arteries from hypertensive rats, whereas reactivity to 5-methoxytryptamine and melatonin in arteries from hypertensive rats did not differ from that in arteries from normotensive rats. Mesenteric arteries from both rat groups were unresponsive to the serotonin metabolite N-acetylserotonin. Contractile responses to 5,6-dihydroxytryptamine and 6-hydroxytryptamine were greater in mesenteric arteries from hypertensive rats, whereas responsiveness to 3-hydroxytryptamine in hypertensive arteries did not differ from normotensive values. Contractile responses to serotonin and its metabolites and to the structurally related monoamines were inhibited by the serotonergic antagonist ketanserin. These results demonstrate that vascular sensitivity to serotonin is increased in DOCA-hypertensive rats. Based on the experiments with serotonin metabolites and with other monoamines, the increased responsiveness to these compounds appears to be related to the structural location of hydroxyl and amine moieties.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalHypertension
Volume9
Issue number3
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

Fingerprint

Mineralocorticoids
Blood Vessels
Serotonin
Hypertension
Mesenteric Arteries
Arteries
Desoxycorticosterone
Acetates
Hydroxytryptophol
5,6-Dihydroxytryptamine
5-Methoxytryptamine
Ketanserin
Melatonin
Acetic Acid
Hydroxyl Radical
Amines
Salts

Keywords

  • Deoxycorticosterone acetate
  • Ketanserin
  • Mesenteric artery
  • Mineralocorticoid hypertensive rats
  • Serotonin
  • Vascular hyperreactivity

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Vascular responsiveness to serotonin metabolites in mineralocorticoid hypertension. / Thompson, Loren P.; Webb, R Clinton.

In: Hypertension, Vol. 9, No. 3, 01.01.1987, p. 277-281.

Research output: Contribution to journalArticle

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