Vascular smooth muscle cell differentiation - 2010

Joseph M. Miano

Research output: Contribution to journalReview article

Abstract

Vascular smooth muscle cells have attracted considerable interest as a model for a flexible program of gene expression. This cell type arises throughout the embryo body plan via poorly understood signaling cascades that direct the expression of transcription factors and microRNAs which, in turn, orchestrate the activation of contractile genes collectively defining this cell lineage. The discovery of myocardin and its close association with serum response factor has represented a major break-through for the molecular understanding of vascular smooth muscle cell differentiation. Retinoids have been shown to improve the outcome of vessel wall remodeling following injury and have provided further insights into the molecular circuitry that defines the vascular smooth muscle cell phenotype. This review summarizes the progress to date in each of these areas of vascular smooth muscle cell biology.

Original languageEnglish (US)
Pages (from-to)169-180
Number of pages12
JournalJournal of Biomedical Research
Volume24
Issue number3
DOIs
StatePublished - May 1 2010
Externally publishedYes

Fingerprint

Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
Cell Differentiation
Cells
Serum Response Factor
Cytology
Retinoids
Cell Lineage
MicroRNAs
Gene expression
Transcriptional Activation
Cell Biology
Transcription Factors
Embryonic Structures
Genes
Chemical activation
Association reactions
Phenotype
Gene Expression

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Vascular smooth muscle cell differentiation - 2010. / Miano, Joseph M.

In: Journal of Biomedical Research, Vol. 24, No. 3, 01.05.2010, p. 169-180.

Research output: Contribution to journalReview article

Miano, Joseph M. / Vascular smooth muscle cell differentiation - 2010. In: Journal of Biomedical Research. 2010 ; Vol. 24, No. 3. pp. 169-180.
@article{1f72b74f4cd847299e27b53253f0946e,
title = "Vascular smooth muscle cell differentiation - 2010",
abstract = "Vascular smooth muscle cells have attracted considerable interest as a model for a flexible program of gene expression. This cell type arises throughout the embryo body plan via poorly understood signaling cascades that direct the expression of transcription factors and microRNAs which, in turn, orchestrate the activation of contractile genes collectively defining this cell lineage. The discovery of myocardin and its close association with serum response factor has represented a major break-through for the molecular understanding of vascular smooth muscle cell differentiation. Retinoids have been shown to improve the outcome of vessel wall remodeling following injury and have provided further insights into the molecular circuitry that defines the vascular smooth muscle cell phenotype. This review summarizes the progress to date in each of these areas of vascular smooth muscle cell biology.",
author = "Miano, {Joseph M.}",
year = "2010",
month = "5",
day = "1",
doi = "10.1016/S1674-8301(10)60026-7",
language = "English (US)",
volume = "24",
pages = "169--180",
journal = "Journal of Biomedical Research",
issn = "1674-8301",
publisher = "Nanjing Medical University",
number = "3",

}

TY - JOUR

T1 - Vascular smooth muscle cell differentiation - 2010

AU - Miano, Joseph M.

PY - 2010/5/1

Y1 - 2010/5/1

N2 - Vascular smooth muscle cells have attracted considerable interest as a model for a flexible program of gene expression. This cell type arises throughout the embryo body plan via poorly understood signaling cascades that direct the expression of transcription factors and microRNAs which, in turn, orchestrate the activation of contractile genes collectively defining this cell lineage. The discovery of myocardin and its close association with serum response factor has represented a major break-through for the molecular understanding of vascular smooth muscle cell differentiation. Retinoids have been shown to improve the outcome of vessel wall remodeling following injury and have provided further insights into the molecular circuitry that defines the vascular smooth muscle cell phenotype. This review summarizes the progress to date in each of these areas of vascular smooth muscle cell biology.

AB - Vascular smooth muscle cells have attracted considerable interest as a model for a flexible program of gene expression. This cell type arises throughout the embryo body plan via poorly understood signaling cascades that direct the expression of transcription factors and microRNAs which, in turn, orchestrate the activation of contractile genes collectively defining this cell lineage. The discovery of myocardin and its close association with serum response factor has represented a major break-through for the molecular understanding of vascular smooth muscle cell differentiation. Retinoids have been shown to improve the outcome of vessel wall remodeling following injury and have provided further insights into the molecular circuitry that defines the vascular smooth muscle cell phenotype. This review summarizes the progress to date in each of these areas of vascular smooth muscle cell biology.

UR - http://www.scopus.com/inward/record.url?scp=78549293286&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78549293286&partnerID=8YFLogxK

U2 - 10.1016/S1674-8301(10)60026-7

DO - 10.1016/S1674-8301(10)60026-7

M3 - Review article

C2 - 23554628

AN - SCOPUS:78549293286

VL - 24

SP - 169

EP - 180

JO - Journal of Biomedical Research

JF - Journal of Biomedical Research

SN - 1674-8301

IS - 3

ER -